Ligand clusters for UniProt code Q12866

Ligand clusters for Q12866: Tyrosine-protein kinase Mer from Homo sapiens

		Top 6 (of 16) ligand clusters Cluster 1. 29 ligand types 37 ligands Cluster 2. 3 ligand types 5 ligands Cluster 3. 4 ligand types 7 ligands Cluster 4. 1 ligand type 1 ligand Cluster 5. 1 ligand type 1 ligand Cluster 6. 1 ligand type 1 ligand
Representative protein: 7aazA

Structures

PDB		Schematic diagram
7aazA
7avyA
4mhaA
6mepA
5k0kA
		more ...

Cluster 1 contains 29 ligand types (of which only 20 are listed. Click for all)

Use checkboxes to select ligands to display in RasMol, Jmol, or download as an SDF file. Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: ADP × 2 Adenosine-5'-Diphosphate PDB codes: 3brb(A),
_Mg		2. Metal: _MG × 4 PDB codes: 2p0c(A), 4m3q(A), 4mh7(A), 6mep(B).
		3. Ligand: C6F × 1 gilteritinib 6-Ethyl-3-[[3-Methoxy-4-[4-(4-Methylpiperazin-1-Yl) piperidin-1-Yl]phenyl]amino]-5-(Oxan-4- Ylamino) pyrazine-2-Carboxamide PDB code: 7ab1(A).
		4. Ligand: ANP × 1 Phosphoaminophosphonic acid-Adenylate ester PDB code: 2p0c(A).
		5. Ligand: OLP × 1 2-(2-Hydroxyethylamino)-6-(3-Chloroanilino)-9- Isopropylpurine PDB code: 3bpr(A).
		6. Ligand: 24K × 2 Trans-4-{[2-(Butylamino)-5-(Pyridin-2-Yl)pyrimidin-4- Yl]amino}cyclohexanol PDB codes: 4m3q(A),
		7. Ligand: 7YS × 2 (10r)-7-Amino-11-Chloro-12-Fluoro-1-(2-Hydroxyethyl)-3, 10,16-Trimethyl-16,17-Dihydro-1h-8,4- (Azeno) pyrazolo[4,3-H][2,5,11]benzoxadiazacyclotetradecin- 15(10h)-One PDB codes: 5u6c(A),
		8. Ligand: 9VS × 2 Cis-4-[(2-[(4-{[4-(1,3-Dioxolan-2-Yl)pyridin-2- Yl]ethynyl}phenyl)amino]-5-{4-[(4-Methylpiperazin- 1- Yl)methyl]phenyl}pyrimidin-4-Yl)amino]cyclohexan-1-Ol PDB codes: 6mep(A),
		9. Ligand: YDJ × 2 5-(3-Fluorophenyl)-N-[(3s)-3-Piperidyl]-3-Ureido- Thiophene-2-Carboxamide PDB codes: 7cqe(A),
		10. Ligand: 4MH × 1 2-(Butylamino)-4-[(Trans-4-Hydroxycyclohexyl)amino]-N- (4-Sulfamoylbenzyl)pyrimidine-5-Carboxamide PDB code: 4mha(A).
		11. Ligand: 6Q1 × 1 15-{4-[(4-Methylpiperazin-1-Yl)methyl]phenyl}-4,5,6,7, 9,10,11,12-Octahydro-2,16- (Azenometheno)pyrrolo[2,1- D][1,3,5,9]tetraazacyclotetradecin-8(3h)-One PDB code: 5k0k(A).
		12. Ligand: 79Y × 1 N-(2-{4-[(2s)-4-(Methylsulfonyl)morpholin-2-Yl]-1,3- Thiazol-2-Yl}phenyl)-1h-Imidazole-2- Carboxamide PDB code: 5tc0(A).
		13. Ligand: 7AE × 1 N-[2-{4-[(2s)-4-(Methylsulfonyl)morpholin-2-Yl]-1,3- Thiazol-2-Yl}-4-(Morpholin-4-Yl)phenyl]-1h- Imidazole- 2-Carboxamide PDB code: 5td2(A).
		14. Ligand: CKJ × 1 1-[(Trans-4-Aminocyclohexyl)methyl]-N-Butyl-3-(4- Fluorophenyl)-1h-Pyrazolo[3,4-D]pyrimidin-6-Amine PDB code: 3tcp(A).
		15. Ligand: EDO × 1 1,2-Ethanediol PDB code: 7oam(A).
		16. Ligand: K0X × 1 (7s)-7-Amino-N-[(4-Fluorophenyl)methyl]-8-Oxo-2,9,16, 18,21-Pentaazabicyclo[15.3.1]henicosa- 1(21),17,19- Triene-20-Carboxamide PDB code: 5k0x(A).
		17. Ligand: L1X × 1 N-(3-Fluoro-4-{[1-Methyl-6-(1h-Pyrazol-4-Yl)-1h- Indazol-5-Yl]oxy}phenyl)-1-(4-Fluorophenyl)-6- Methyl- 2-Oxo-1,2-Dihydropyridine-3-Carboxamide PDB code: 7aay(A).
		18. Ligand: MH7 × 1 N-Butyl-2-(Butylamino)-4-[(Trans-4-Hydroxycyclohexyl) amino]-N-Methylpyrimidine-5-Carboxamide PDB code: 4mh7(A).
		19. Ligand: R6H × 1 ~{N}-[4-(6,7-Dimethoxyquinolin-4-Yl)oxy-3-Fluoranyl- Phenyl]-4-Ethoxy-1-(4-Fluoranyl-2-Methyl- Phenyl) pyrazole-3-Carboxamide PDB code: 7aax(A).
		20. Ligand: R6K × 1 2-Azanyl-~{N}-[(1~{s},2~{s})-2-[[4-[4-[(4- Methylpiperazin-1- Yl) methyl]phenyl]phenyl]methoxy]cyclopentyl]-5-(1- Methylpyrazol-4-Yl)pyridine-3-Carboxamide PDB code: 7aaz(A).
+ more. Press for full list

Cluster 2 contains 3 ligand types

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: DMS × 2 dimethyl sulfoxide Dimethyl sulfoxide PDB codes: 7ab1(A), 7ab2(A).
		2. Ligand: GOL × 1 glycerin Glycerol PDB code: 3brb(A).
		3. Ligand: EDO × 2 1,2-Ethanediol PDB codes: 7aw4(A),

Cluster 3 contains 4 ligand types

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: DMS × 1 dimethyl sulfoxide Dimethyl sulfoxide PDB code: 7ab2(A).
_Cl		2. Metal: _CL × 4 PDB codes: 4m3q(A), 4mh7(B), 5k0k(A), 6mep(A).
		3. Ligand: EDO × 1 1,2-Ethanediol PDB code: 7oam(A).
		4. Ligand: SO4 × 1 Sulfate ion PDB code: 7avy(A).

Cluster 4 contains 1 ligand type

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 3brb(B).

Cluster 5 contains 1 ligand type

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: SO4 × 1 Sulfate ion PDB code: 7avy(A).

Cluster 6 contains 1 ligand type

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: SO4 × 1 Sulfate ion PDB code: 7avy(A).