Ligand clusters for UniProt code Q07343

Ligand clusters for Q07343: cAMP-specific 3',5'-cyclic phosphodiesterase 4B from Homo sapiens

		Top 6 (of 27) ligand clusters Cluster 1. 43 ligand types 130 ligands Cluster 2. 1 ligand type 1 ligand Cluster 3. 1 ligand type 1 ligand Cluster 4. 2 ligand types 4 ligands Cluster 5. 2 ligand types 9 ligands Cluster 6. 2 ligand types 3 ligands
Representative protein: 4wziA

Structures

PDB		Schematic diagram
4wziA
4x0fA
3kktA
1ro9A
1rorA
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Cluster 1 contains 43 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: AMP × 2 Adenosine monophosphate PDB codes: 1ror(A), 1tb5(A).
_Zn		2. Metal: _ZN × 42 PDB codes: 1f0j(A), 1ro6(A), 1ro9(A), 1ror(A), 1tb5(A), 1xlx(A), 1xlz(A), 1xm4(A), 1xm6(A), 1xmu(A), 1xmy(A), 1xn0(A), 1xos(A), 1xot(B), 1y2h(A), 1y2j(A), 2chm(A), 2qyl(A), 3d3p(A), 3frg(A), 3g45(A), 3gwt(A), 3hmv(A), 3kkt(A), 3ly2(A), 3o0j(A), 3o56(A), 3o57(A), 3w5e(A), 3wd9(A), 4kp6(A), 4myq(A), 4nw7(A), 4wzi(A), 4x0f(A), 5k6j(A), 5laq(A), 5ohj(A), 6boj(A).
_Mg		3. Metal: _MG × 35 PDB codes: 1f0j(A), 1tb5(A), 1xlx(A), 1xlz(A), 1xm4(A), 1xm6(A), 1xmu(A), 1xmy(A), 1xn0(A), 1xos(A), 1xot(B), 1y2h(A), 1y2j(A), 2chm(A), 2qyl(A), 3d3p(A), 3frg(A), 3g45(A), 3gwt(A), 3hmv(A), 3kkt(A), 3ly2(A), 3o0j(A), 3o56(A), 3o57(A), 4kp6(A), 4myq(A), 4nw7(A), 4wzi(A), 4x0f(A), 5k6j(A), 5laq(A), 5ohj(A), 6boj(A).
		4. Ligand: GOL × 2 glycerin Glycerol PDB codes: 3frg(A), 3gwt(A).
		5. Ligand: ROF × 1 roflumilast 3-(Cyclopropylmethoxy)-N-(3,5-Dichloropyridin-4-Yl)-4- (Difluoromethoxy)benzamide PDB code: 1xmu(A).
		6. Ligand: VDN × 1 vardenafil 2-{2-Ethoxy-5-[(4-Ethylpiperazin-1-Yl)sulfonyl]phenyl}- 5-Methyl-7-Propylimidazo[5,1- F][1,2,4]triazin-4(1h)- One PDB code: 1xot(B).
		7. Ligand: VIA × 1 sildenafil 5-{2-Ethoxy-5-[(4-Methylpiperazin-1-Yl) sulfonyl]phenyl}-1-Methyl-3-Propyl-1h,6h,7h- Pyrazolo[4,3- D]pyrimidin-7-One PDB code: 1xos(A).
_Mn		8. Metal: _MN × 1 PDB code: 1ro6(A).
		9. Ligand: 8BR × 1 8-Bromo-Adenosine-5'-Monophosphate PDB code: 1ro9(A).
		10. Ligand: ROL × 4 Rolipram PDB codes: 1ro6(A), 1xmy(A), 1xn0(A),
		11. Ligand: FIL × 1 (1e)-1-[3-(Cyclopentyloxy)-4-Methoxyphenyl]ethanone o- (Aminocarbonyl)oxime PDB code: 1xlz(A).
		12. Ligand: SO4 × 1 Sulfate ion PDB code: 1xos(A).
		13. Ligand: 5RM × 1 (5r)-5-(4-Methoxy-3-Propoxyphenyl)-5-Methyl-1,3- Oxazolidin-2-One PDB code: 1xm6(A).
		14. Ligand: 6DE × 1 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4- Carboxylic acid ethyl ester PDB code: 1y2h(A).
		15. Ligand: CIO × 1 Cilomilast PDB code: 1xlx(A).
		16. Ligand: PIL × 1 3-(Cyclopentyloxy)-N-(3,5-Dichloropyridin-4-Yl)-4- Methoxybenzamide PDB code: 1xm4(A).
		17. Ligand: 3P4 × 1 5-[2-(But-3-En-1-Yloxy)-5-(1-Hydroxyvinyl)pyridin-3- Yl]-3-Ethyl-2-(1-Ethylazetidin-3-Yl)-1,2,6,7a- Tetrahydro-7h-Pyrazolo[4,3-D]pyrimidin-7-One PDB code: 2chm(A).
		18. Ligand: 7DE × 1 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic acid ethyl ester PDB code: 1y2j(A).
		19. Ligand: ROL × 2 Rolipram PDB codes: 1jp2(A), 4x0f(A).
		20. Ligand: EDO × 5 1,2-Ethanediol PDB codes: 3o0j(A), 4kp6(A), 4nw7(A), 5k6j(A).
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Cluster 2 contains 1 ligand type

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Ligand		Description
		1. Ligand: ROL × 1 Rolipram PDB code: 4x0f(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: MES × 1 2-(N-Morpholino)-Ethanesulfonic acid PDB code: 2chm(A).

Cluster 4 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 2 glycerin Glycerol PDB codes: 3frg(A), 3gwt(A).
		2. Ligand: EDO × 2 1,2-Ethanediol PDB codes: 3o0j(A), 4kp6(A).

Cluster 5 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 2 glycerin Glycerol PDB codes: 3gwt(A), 3o57(A).
		2. Ligand: EDO × 7 1,2-Ethanediol PDB codes: 3o0j(A), 4kp6(A), 4myq(A), 5k6j(A),

Cluster 6 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 3o56(A).
		2. Ligand: EDO × 2 1,2-Ethanediol PDB codes: 4myq(A), 4nw7(A).