Ligand clusters for UniProt code P54646

Ligand clusters for P54646: 5'-AMP-activated protein kinase catalytic subunit alpha-2 from Homo sapiens

		3 ligand clusters Cluster 1. 4 ligand types 12 ligands Cluster 2. 3 ligand types 10 ligands Cluster 3. 1 ligand type 5 ligands
Representative protein: 4zhxC

Structures

PDB		Schematic diagram
4zhxC
4cfeA
4cfeC
4cffA
5ezvA
		more ...

Cluster 1 contains 4 ligand types

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Ligand		Description
		1. Ligand: STU × 8 Staurosporine PDB codes: 4cfe(A), 4cff(A), 5ezv(A), 5iso(A), 6b1u(A), 6b2e(A).
		2. Ligand: 4O7 × 2 (5s,6r,7r,9r,13cr,14r,16as)-6-Methoxy-5-Methyl-7- (Methylamino)-6,7,8,9,14,15,16,16a-Octahydro- 5h,13ch- 5,9-Epoxy-4b,9a,15-Triazadibenzo[b,H]cyclonona[1,2,3, 4-Jkl]cyclopenta[e]-As-Indacen-14- Ol PDB codes: 4zhx(A),
		3. Ligand: EDJ × 1 2-({5-Bromo-2-[(3,4,5-Trimethoxyphenyl)amino]pyrimidin- 4-Yl}oxy)-N-Methylbenzene-1- Carboximidic acid PDB code: 6bx6(A).
		4. Ligand: TAK × 1 6-[4-(2-Piperidin-1-Ylethoxy)phenyl]-3-Pyridin-4- Ylpyrazolo[1,5-A]pyrimidine PDB code: 3aqv(A).

Cluster 2 contains 3 ligand types

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Ligand		Description
		1. Ligand: 992 × 4 5-[[6-Chloranyl-5-(1-Methylindol-5-Yl)-1h-Benzimidazol- 2-Yl]oxy]-2-Methyl-Benzoic acid PDB codes: 4cfe(A), 5iso(A),
		2. Ligand: C1V × 4 3-[4-(2-Hydroxyphenyl)phenyl]-4-Oxidanyl-6- Oxidanylidene-7h-Thieno[2,3-B]pyridine-5-Carbonitrile PDB codes: 4cff(A), 4zhx(A), 5ezv(A).
		3. Ligand: CG7 × 2 5-{[6-Chloro-5-(2'-Hydroxy[1,1'-Biphenyl]-4-Yl)-1h- Imidazo[4,5-B]pyridin-2-Yl]oxy}-2- Methylbenzoic acid PDB codes: 6b1u(A), 6b2e(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: AMP × 5 Adenosine monophosphate PDB codes: 4zhx(C), 5iso(A), 6b1u(A), 6b2e(A).