Ligand clusters for UniProt code P49137

Ligand clusters for P49137: MAP kinase-activated protein kinase 2 from Homo sapiens

		Top 6 (of 14) ligand clusters Cluster 1. 21 ligand types 29 ligands Cluster 2. 2 ligand types 3 ligands Cluster 3. 1 ligand type 1 ligand Cluster 4. 1 ligand type 2 ligands Cluster 5. 1 ligand type 1 ligand Cluster 6. 1 ligand type 2 ligands
Representative protein: 6tcaA

Structures

PDB		Schematic diagram
6tcaA
4tyhA
3fyjX
3m2wA
2p3gX
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Cluster 1 contains 21 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: ADP × 1 Adenosine-5'-Diphosphate PDB code: 1ny3(A).
		2. Ligand: STU × 2 Staurosporine PDB codes: 1nxk(A),
		3. Ligand: PO4 × 1 Phosphate ion PDB code: 2jbo(A).
		4. Ligand: F10 × 1 2-[2-(2-Fluorophenyl)pyridin-4-Yl]-1,5,6,7-Tetrahydro- 4h-Pyrrolo[3,2-C]pyridin-4-One PDB code: 2p3g(X).
		5. Ligand: P4O × 5 2-(2-Quinolin-3-Ylpyridin-4-Yl)-1,5,6,7- Tetrahydro-4h-Pyrrolo[3,2-C]pyridin-4-One PDB codes: 2jbo(A), 2jbp(A), 3gok(A), 3r2y(A).
		6. Ligand: STU × 1 Staurosporine PDB code: 2pzy(C).
		7. Ligand: B97 × 2 (10r)-10-Methyl-3-(6-Methylpyridin-3-Yl)-9,10,11,12- Tetrahydro-8h- [1,4]diazepino[5',6':4,5]thieno[3,2- F]quinolin-8-One PDB codes: 3fyj(X), 6t8x(A).
		8. Ligand: MK2 × 2 N~4~-[7-(1-Benzofuran-2-Yl)-1h-Indazol-5-Yl]pyrimidine- 2,4-Diamine PDB codes: 3kc3(A),
		9. Ligand: PDY × 2 N~7~-(4-Ethoxyphenyl)-6-Methyl-N~5~-[(3s)-Piperidin-3- Yl]pyrazolo[1,5-A]pyrimidine-5,7-Diamine PDB codes: 3a2c(A),
		10. Ligand: 05B × 1 2'-[2-(1,3-Benzodioxol-5-Yl)pyrimidin-4-Yl]-5',6'- Dihydrospiro[piperidine-4,7'-Pyrrolo[3,2- C]pyridin]- 4'(1'H)-One PDB code: 3r2b(A).
		11. Ligand: 793 × 1 3-{[(1r)-1-Phenylethyl]amino}-4-(Pyridin-4-Ylamino) cyclobut-3-Ene-1,2-Dione PDB code: 3fpm(A).
		12. Ligand: B18 × 1 (4r)-N-[4-({[2-(Dimethylamino)ethyl]amino}carbonyl)-1, 3-Thiazol-2-Yl]-4-Methyl-1-Oxo-2,3,4,9- Tetrahydro-1h- Beta-Carboline-6-Carboxamide PDB code: 2pzy(A).
		13. Ligand: B98 × 1 (3r)-3-(Aminomethyl)-9-Methoxy-1,2,3,4-Tetrahydro-5h- [1]benzothieno[3,2-E][1,4]diazepin-5-One PDB code: 3fyk(X).
		14. Ligand: CD2 × 1 1-(2-Aminoethyl)-3-[2-(Quinolin-3-Yl)pyridin-4-Yl]-1h- Pyrazole-5-Carboxylic acid PDB code: 3r30(A).
		15. Ligand: HGF × 1 2-[5-(2-Methoxyethoxy)pyridin-3-Yl]-8,9,10,11- Tetrahydro-7h-Pyrido[3',4':4,5]pyrrolo[2,3- F]isoquinolin-7-One PDB code: 3m42(A).
		16. Ligand: L8I × 1 2'-(2-Fluorophenyl)-1-Methyl-6',8',9',11'- Tetrahydrospiro[azetidine-3,10'- Pyrido[3',4':4, 5]pyrrolo[2,3-F]isoquinolin]-7'(5'H)-One PDB code: 3m2w(A).
		17. Ligand: LX9 × 1 6-{3-Amino-1-[3-(1h-Indol-6-Yl)phenyl]-1h-Pyrazol-4- Yl}-3,4-Dihydroisoquinolin-1(2h)-One PDB code: 3kga(A).
		18. Ligand: MK3 × 1 6-{5-[(2-Aminopyrimidin-4-Yl)amino]-2-Hydroxyphenyl}-N- Methylidene-1-Benzothiophene-2-Carboxamide PDB code: 3ka0(A).
		19. Ligand: MLI × 1 Malonate ion PDB code: 3r2y(A).
		20. Ligand: YRZ × 1 N-[(3s)-Piperidin-3-Yl]-7,8-Dihydro-6h-Pyrazolo[1,5- A]pyrrolo[3,2-E]pyrimidin-5-Amine PDB code: 3wi6(A).
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Cluster 2 contains 2 ligand types

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Ligand		Description
		1. Ligand: PDY × 2 N~7~-(4-Ethoxyphenyl)-6-Methyl-N~5~-[(3s)-Piperidin-3- Yl]pyrazolo[1,5-A]pyrimidine-5,7-Diamine PDB codes: 3a2c(A),
		2. Ligand: MW8 × 1 5-(4-Bromophenyl)-~{N}-(4-Piperazin-1-Ylphenyl)-~{N}- (Pyridin-2-Ylmethyl)furan-2-Carboxamide PDB code: 6t8x(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: MW8 × 1 5-(4-Bromophenyl)-~{N}-(4-Piperazin-1-Ylphenyl)-~{N}- (Pyridin-2-Ylmethyl)furan-2-Carboxamide PDB code: 6t8x(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: 39G × 2 N-[5-(Dimethylsulfamoyl)-2-Methylphenyl]-1-Phenyl-5- Propyl-1h-Pyrazole-4-Carboxamide PDB codes: 4tyh(A), 6tca(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: MLI × 1 Malonate ion PDB code: 3r2y(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
		1. Ligand: SO4 × 2 Sulfate ion PDB codes: 1nxk(A),