Ligand clusters for UniProt code P22756

Ligand clusters for P22756: Glutamate receptor ionotropic, kainate 1 from Rattus norvegicus

		Top 6 (of 32) ligand clusters Cluster 1. 25 ligand types 54 ligands Cluster 2. 7 ligand types 24 ligands Cluster 3. 4 ligand types 9 ligands Cluster 4. 3 ligand types 3 ligands Cluster 5. 1 ligand type 1 ligand Cluster 6. 3 ligand types 13 ligands
Representative protein: 3gbaA

Structures

PDB		Schematic diagram
3gbaA
2ojtA
2qs2A
4ymbA
2qs3A
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Cluster 1 contains 25 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: GOL × 15 glycerin Glycerol PDB codes: 1vso(A), 3c31(A), 3c32(A), 3c33(A), 3c34(A), 3c35(A), 3c36(A), 5mfq(A), 5mfv(A), 5mfw(A), 5nf5(B), 6fz4(A).
		2. Ligand: KAI × 10 3-(Carboxymethyl)-4-Isopropenylproline PDB codes: 3c31(A), 3c32(A), 3c33(A), 3c34(A), 3c35(A), 3c36(A), 4e0x(A), 5mfq(A), 5mfv(A), 5mfw(A).
		3. Ligand: GLU × 3 PDB codes: 1txf(A), 1ycj(A), 2f36(A).
		4. Ligand: SO4 × 3 Sulfate ion PDB codes: 4qf9(A), 6fz4(A), 6sbt(A).
		5. Ligand: UBA × 2 (S)-1-(2-Amino-2-Carboxyethyl)-3(2-Carboxythiophene-3- Yl-Methyl)-5-Methylpyrimidine-2,4-Dione PDB codes: 2f34(A), 2ojt(A).
_Cl		6. Metal: _CL × 2 PDB codes: 4ymb(A), 6sbt(A).
		7. Ligand: 35K × 1 (2s)-2-Amino-4-(2,3-Dioxo-1,2,3,4-Tetrahydroquinoxalin- 6-Yl)butanoic acid PDB code: 4qf9(A).
		8. Ligand: 3HU × 1 (S)-1-(2'-Amino-2'-Carboxyethyl)-3-[(2-Carboxythien-3- Yl)methyl]thieno[3,4-D]pyrimidin-2,4-Dione PDB code: 3s2v(A).
		9. Ligand: 4E7 × 1 (3r,4s)-3-(3-Carboxyphenyl)-4-Propyl-L-Proline PDB code: 4ymb(A).
		10. Ligand: 7E5 × 1 (2~{s},4~{r})-4-(2-Carboxyphenoxy)pyrrolidine-2- Carboxylic acid PDB code: 5m2v(A).
		11. Ligand: 8VE × 1 (3~{a}~{r},4~{s},6~{a}~{r})-1-Methyl-4,5,6,6~{a}- Tetrahydro-3~{a}~{h}-Pyrrolo[3,4-C]pyrazole-3,4- Dicarboxylic acid PDB code: 5neb(B).
		12. Ligand: 8VN × 1 (3~{a}~{s},4~{s},6~{a}~{r})-4,5,6,6~{a}-Tetrahydro- 3~{a}~{h}-Pyrrolo[3,4-D][1,2]oxazole-3,4- Dicarboxylic acid PDB code: 5nf5(B).
		13. Ligand: AT1 × 1 (S)-2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4- Isoxazolyl)propionic acid PDB code: 1vso(A).
		14. Ligand: DOQ × 1 (2s,3s,4s)-2-Carboxy-4-[(1z,3e,5r)-5-Carboxy-1-Methyl- 1,3-Hexadienyl]-3-Pyrrolidineacetic acid PDB code: 2pbw(A).
		15. Ligand: DYH × 1 (2r,3ar,6s,7r,7ar)-2-[(2s)-2-Amino-2-Carboxyethyl]-6- Hydroxy-7-(Methylamino)hexahydro-2h-Furo[3,2- B]pyran- 2-Carboxylic acid PDB code: 3gba(A).
		16. Ligand: EC8 × 1 N-(7-Fluoro-2,3-Dioxo-6-(Trifluoromethyl)-3,4- Dihydroquinoxalin-1(2h)-Yl)-2-Hydroxybenzamide PDB code: 6fz4(A).
		17. Ligand: IBC × 1 3-(3-Hydroxy-7,8-Dihydro-6h-Cyclohepta[d]isoxazol-4- Yl)-L-Alanine PDB code: 2wky(A).
		18. Ligand: L5H × 1 ~{N}-[7-Imidazol-1-Yl-2,3-Bis(oxidanylidene)-6- (Trifluoromethyl)-4~{h}-Quinoxalin-1-Yl]benzamide PDB code: 6sbt(A).
		19. Ligand: LY5 × 1 (3s,4ar,6s,8ar)-6-{[(2s)-2-Carboxy-4,4- Difluoropyrrolidin-1-Yl]methyl}decahydroisoquinoline- 3- Carboxylic acid PDB code: 2qs4(A).
		20. Ligand: MS8 × 1 (2r,3ar,7ar)-2-[(2s)-2-Amino-3-Hydroxy-3-Oxo-Propyl]-3, 3a,5,6,7,7a-Hexahydrofuro[4,5-B]pyran-2- Carboxylic acid PDB code: 3gbb(A).
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Cluster 2 contains 7 ligand types

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Ligand		Description
		1. Ligand: GOL × 7 glycerin Glycerol PDB codes: 3c31(A), 3c32(A), 3c33(A), 3c35(A), 3c36(A), 6fz4(A), 6sbt(A).
		2. Ligand: SO4 × 9 Sulfate ion PDB codes: 1ycj(A), 2f36(A), 3gba(A), 3s2v(A), 5m2v(A), 5mfv(A), 5neb(B).
		3. Ligand: 2J9 × 2 4-Cyclopropyl-7-Fluoro-3,4-Dihydro-2h-1,2,4- Benzothiadiazine 1,1-Dioxide PDB codes: 5mfq(A),
		4. Ligand: 5PX × 2 4-Cyclopropyl-3,4-Dihydro-7-Hydroxy-2h-1,2,4- Benzothiadiazine 1,1-Dioxide PDB codes: 5mfv(A),
		5. Ligand: 7M6 × 2 7-Chloro-4-(2-Fluoroethyl)-2,3-Dihydro-1,2,4- Benzothiadiazine 1,1-Dioxide PDB codes: 5mfw(A),
		6. Ligand: ACT × 1 Acetate ion PDB code: 4qf9(A).
_Cl		7. Metal: _CL × 1 PDB code: 5neb(B).

Cluster 3 contains 4 ligand types

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Ligand		Description
		1. Ligand: 1PE × 6 Pentaethylene glycol PDB codes: 2f34(A), 2f35(A), 2ojt(A), 2qs1(A), 2qs2(A), 2qs3(A).
		2. Ligand: SO4 × 1 Sulfate ion PDB code: 5mfw(A).
_Cs		3. Metal: _CS × 1 PDB code: 3c35(A).
_Rb		4. Metal: _RB × 1 PDB code: 3c34(A).

Cluster 4 contains 3 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 6fz4(A).
		2. Ligand: PEG × 1 Di(hydroxyethyl)ether PDB code: 4ymb(A).
		3. Ligand: SO4 × 1 Sulfate ion PDB code: 1ycj(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: PG4 × 1 Tetraethylene glycol PDB code: 4qf9(A).

Cluster 6 contains 3 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 3c34(A).
		2. Ligand: SO4 × 6 Sulfate ion PDB codes: 1ycj(A), 4e0x(A), 5m2v(A), 5mfw(A), 5neb(B), 6sbt(A).
_Cl		3. Metal: _CL × 6 PDB codes: 3c31(A), 3c32(A), 3c33(A), 3c34(A), 3c36(A), 4ymb(A).