Ligand clusters for UniProt code P19491

Ligand clusters for P19491: Glutamate receptor 2 from Rattus norvegicus

		Top 6 (of 37) ligand clusters Cluster 1. 62 ligand types 292 ligands Cluster 2. 70 ligand types 388 ligands Cluster 3. 14 ligand types 34 ligands Cluster 4. 6 ligand types 6 ligands Cluster 5. 4 ligand types 38 ligands Cluster 6. 4 ligand types 5 ligands
Representative protein: 5weoA

Structures

PDB		Schematic diagram
5weoA
5welA
5wenA
4u2pA
4u5cA
		more ...

Cluster 1 contains 62 ligand types (of which only 20 are listed. Click for all)

Use checkboxes to select ligands to display in RasMol, Jmol, or download as an SDF file. Selection shortcuts: select all/none invert selection.
Ligand		Description
_Zn		1. Metal: _ZN × 66 PDB codes: 1ftj(A), 1ftm(A), 1lbc(A), 1m5b(A), 1m5e(A), 1m5f(A), 1mm7(A), 1mqj(A), 1ms7(A), 1mxu(A), 1mxv(A), 1mxw(A), 1mxx(A), 1mxy(A), 1mxz(A), 1my0(A), 1my1(A), 1my2(A), 1my3(A), 1my4(A), 1nnk(A), 1p1q(A), 2al4(A), 2gfe(A), 2i3v(A), 2uxa(A), 2xx7(A), 2xx8(A), 2xx9(A), 2xxh(A), 2xxi(A), 3bft(A), 3dp6(A), 3h03(A), 3h6t(A), 3ijo(B), 3ijx(B), 3ik6(B), 3il1(B), 3ilt(B), 3ilu(B), 3lsf(B), 3lsl(A), 3m3l(A), 3pd8(A), 3rtf(B), 3rtw(B), 3t93(B), 3t96(B), 3t9h(B), 3t9u(A), 3t9v(A), 3t9x(B), 4gxs(B), 4lz5(A), 4lz7(A), 4lz8(A), 4n07(A), 4o3a(A), 4q30(B), 4x48(A), 5fth(A), 5oew(A), 6hch(A).
		2. Ligand: GOL × 46 glycerin Glycerol PDB codes: 1mm6(A), 1mqd(A), 1mqg(A), 1wvj(A), 3h6t(A), 3h6u(A), 3h6v(A), 3o28(A), 3o29(A), 3o2a(A), 3pd8(A), 3pd9(A), 3pmv(A), 3pmx(A), 3tdj(A), 4fat(A), 4igt(A), 4o3a(A), 4o3b(A), 4yma(B), 5cbr(A), 5elv(A), 5fhm(A), 5fho(A), 6faz(A), 6giv(A), 6gl4(A), 6hcb(A), 6hcc(A), 6hch(A), 6q60(A), 6yk2(A), 6yk3(A), 6yk4(A), 6yk5(A), 6yk6(A).
		3. Ligand: CYZ × 18 cyclothiazide Cyclothiazide PDB codes: 1lbc(A), 3h6t(A), 3tkd(A), 5weo(A), 6dlz(A), 6dm0(A), 6dm1(A), 6dm2(A), 6o9g(A),
		4. Ligand: PZI × 9 piracetam 2-(2-Oxopyrrolidin-1-Yl)acetamide PDB codes: 3lsf(B), 3lsl(A),
		5. Ligand: HCZ × 4 hydrochlorothiazide 6-Chloro-3,4-Dihydro-2h-1,2,4-Benzothiadiazine-7- Sulfonamide 1,1-Dioxide PDB codes: 3ijx(B), 3ik6(B),
		6. Ligand: DMS × 2 dimethyl sulfoxide Dimethyl sulfoxide PDB codes: 3o6h(A), 3pmw(A).
		7. Ligand: HFZ × 2 hydroflumethiazide 6-(Trifluoromethyl)-3,4-Dihydro-2h-1,2,4- Benzothiadiazine-7-Sulfonamide 1,1-Dioxide PDB codes: 3ilu(B),
		8. Ligand: ACY × 1 acetic acid Acetic acid PDB code: 3pd8(A).
		9. Ligand: SO4 × 31 Sulfate ion PDB codes: 1xhy(A), 2cmo(A), 2xx7(A), 2xx8(A), 2xx9(A), 2xxh(A), 2xxi(A), 3h6u(A), 3o6g(A), 3o6i(A), 3pmw(A), 4g8m(A), 4igt(A), 4o3b(A), 5buu(A), 5fhm(A), 5fho(A), 5o9a(A), 6hc9(A), 6hca(A), 6hcb(A), 6q54(A), 6yk5(A), 6yk6(A).
		10. Ligand: ACT × 15 Acetate ion PDB codes: 1m5f(A), 4n07(A), 4o3c(A), 4u4s(A), 4u4x(A), 4yma(B), 5elv(A), 5oew(A), 6faz(A), 6hcc(A), 6hch(A).
		11. Ligand: EDO × 14 1,2-Ethanediol PDB codes: 3o6h(A), 3pmx(A), 5buu(A), 5cbs(A), 5fhm(A), 5fhn(A), 5fho(A), 5o9a(A), 6faz(A).
		12. Ligand: FWF × 13 N,N'-[Biphenyl-4,4'-Diyldi(2r)propane-2,1- Diyl]dipropane-2-Sulfonamide PDB codes: 4u1o(A), 4u1w(A), 4u1x(A), 4u1y(A), 4u1z(A), 4u21(A), 4u22(A), 4u23(A), 4u5b(A), 4u5c(A), 4u5d(A), 4u5e(A), 4u5f(A).
		13. Ligand: PEG × 4 Di(hydroxyethyl)ether PDB codes: 4o3b(A), 4yu0(A), 5jei(A).
		14. Ligand: D45 × 3 6,6'-(Ethane-1,2-Diyl)bis(4-Methyl-3,4-Dihydro-2h-1,2, 4-Benzothiadiazine 1,1-Dioxide) PDB codes: 6faz(A), 6hcb(A), 6hch(A).
		15. Ligand: FXW × 3 6,6'-(Ethane-1,2-Diyl)bis(4-Cyclopropyl-3,4-Dihydro-2h- 1,2,4-Benzothiadiazine 1,1-Dioxide) PDB codes: 6hc9(A), 6hca(A), 6hcc(A).
		16. Ligand: 3C1 × 2 4-Ethyl-3,4-Dihydro-2h-Pyrido[4,3-E][1,2,4]thiadiazine 1,1-Dioxide PDB codes: 4u4s(A),
		17. Ligand: 3C2 × 2 4-Ethyl-3,4-Dihydro-2h-Pyrido[3,2-E][1,2,4]thiadiazine 1,1-Dioxide PDB codes: 4u4x(A),
		18. Ligand: 3TJ × 2 4-Ethyl-7-Fluoro-3,4-Dihydro-2h-1,2,4-Benzothiadiazine 1,1-Dioxide PDB codes: 3tdj(A),
		19. Ligand: 4V6 × 2 (3r)-7-Chloro-2,3,4-Trimethyl-3,4-Dihydro-2h-1,2,4- Benzothiadiazine 1,1-Dioxide PDB codes: 5buu(A),
		20. Ligand: 5PX × 2 4-Cyclopropyl-3,4-Dihydro-7-Hydroxy-2h-1,2,4- Benzothiadiazine 1,1-Dioxide PDB codes: 5elv(A),
+ more. Press for full list

Cluster 2 contains 70 ligand types (of which only 20 are listed. Click for all)

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: GOL × 39 glycerin Glycerol PDB codes: 3bbr(A), 3h6u(A), 3h6w(A), 3o28(A), 3o29(A), 3o2a(A), 3pmv(A), 3pmw(A), 3pmx(A), 3tdj(A), 4fat(A), 4g8m(A), 4iy5(A), 4iy6(A), 4o3a(A), 4u4s(A), 4u4x(A), 5cbr(A), 5elv(A), 5fhn(A), 5fti(A), 5ng9(A), 5o9a(A), 6faz(A), 6giv(A), 6hc9(A), 6hca(A), 6hcb(A), 6hcc(A), 6q60(A), 6yk3(A).
_Zn		2. Metal: _ZN × 7 PDB codes: 1nnk(A), 4n07(A), 4o3a(A), 5fth(C), 6hch(A).
		3. Ligand: ASP × 2 aspartic acid PDB codes: 4o3a(A), 4o3c(A).
		4. Ligand: CIT × 1 citric acid Citric acid PDB code: 6q54(A).
		5. Ligand: SO4 × 101 Sulfate ion PDB codes: 1mm6(A), 1mqd(A), 1mqg(A), 1nnp(A), 1p1o(A), 1p1u(A), 1p1w(A), 1wvj(A), 1xhy(A), 2cmo(A), 2p2a(A), 3b6q(A), 3b6t(A), 3b6w(A), 3bbr(A), 3h6u(A), 3h6v(A), 3h6w(A), 3kgc(A), 3o28(A), 3o29(A), 3o2a(A), 3o6g(A), 3o6h(A), 3o6i(A), 3pd9(A), 3pmv(A), 3pmw(A), 3pmx(A), 3tdj(A), 3tkd(A), 3tza(A), 4fat(A), 4g8m(A), 4h8j(A), 4igt(A), 4isu(A), 4iy5(A), 4iy6(A), 4l17(A), 4o3b(A), 4o3c(A), 4u2r(B), 4u4s(A), 4u4x(A), 4yma(B), 5buu(A), 5cbr(A), 5cbs(A), 5elv(A), 5fhm(A), 5fhn(A), 5fho(A), 5fti(A), 5ng9(A), 5ns9(A), 5o9a(A), 6faz(A), 6giv(A), 6hc9(A), 6hca(A), 6hcb(A), 6hcc(A), 6q54(A), 6q60(A), 6yk2(A), 6yk3(A), 6yk4(A), 6yk5(A), 6yk6(A).
		6. Ligand: GLU × 78 PDB codes: 1ftj(A), 1lbc(A), 2gfe(A), 2i3v(A), 2i3w(A), 2p2a(A), 2uxa(A), 2xx7(A), 2xx8(A), 2xx9(A), 2xxh(A), 2xxi(A), 3b6q(A), 3b6w(A), 3bbr(A), 3dp6(A), 3h6t(A), 3h6u(A), 3h6v(A), 3h6w(A), 3ijo(B), 3ijx(B), 3ik6(B), 3il1(B), 3ilt(B), 3ilu(B), 3kgc(A), 3lsf(B), 3lsl(A), 3m3l(A), 3o28(A), 3o29(A), 3o2a(A), 3o6g(A), 3o6h(A), 3o6i(A), 3pmv(A), 3pmw(A), 3pmx(A), 3t93(B), 3t9x(B), 3tdj(A), 3tkd(A), 4fat(A), 4iy5(A), 4iy6(A), 4lz5(A), 4lz7(A), 4lz8(A), 4n07(A), 4u4s(A), 4u4x(A), 4uq6(A), 4x48(A), 4yu0(A), 4z0i(A), 5buu(A), 5elv(A), 5fth(A), 5fti(A), 5ns9(A), 5o9a(A), 5oew(A), 5weo(A), 6dlz(A), 6dm0(A), 6dm1(A), 6dm2(A), 6faz(A), 6giv(A), 6gl4(A), 6hc9(A), 6hcb(A), 6hcc(A), 6hch(A), 6o9g(A).
		7. Ligand: ZK1 × 19 {[7-Morpholin-4-Yl-2,3-Dioxo-6-(Trifluoromethyl)-3,4- Dihydroquinoxalin-1(2h)- Yl]methyl}phosphonic acid PDB codes: 3kg2(A), 4u4g(A), 4uqj(A), 5kbs(A), 5kbt(A), 5kbu(A), 5kbv(A), 5vhw(A), 5vhx(A), 5vhy(A), 5wek(A), 5wel(A), 6fqj(A), 6fqk(A), 6peq(A), 6ruq(A), 6ucb(A), 6ud4(A), 6ud8(A).
		8. Ligand: KAI × 17 3-(Carboxymethyl)-4-Isopropenylproline PDB codes: 1ftk(A), 1fw0(A), 1gr2(A), 1lbb(A), 1p1n(A), 1xhy(A), 2anj(A), 3t9h(B), 4u1o(A), 4u1w(A), 4u1x(A), 4u1z(A), 4u2q(A), 4u5b(A), 4u5d(A), 4u5e(A), 4u5f(A).
		9. Ligand: EDO × 11 1,2-Ethanediol PDB codes: 3o6g(A), 3pmx(A), 5cbs(A), 5fhm(A), 5fho(A), 5jei(A).
		10. Ligand: FWD × 8 2-Amino-3-(5-Fluoro-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin- 1-Yl)-Propionic acid PDB codes: 1mqi(A), 2al5(A), 4u1y(A), 4u21(A), 4u22(A), 4u23(A), 4u5c(A), 5jei(A).
		11. Ligand: QUS × 7 (S)-2-Amino-3-(3,5-Dioxo-[1,2,4]oxadiazolidin-2-Yl)- Propionic acid PDB codes: 1mm6(A), 1mm7(A), 1p1o(A), 2al4(A), 3b6t(A), 4uqk(A), 5vhz(A).
		12. Ligand: AMQ × 6 (S)-Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic acid PDB codes: 1ftm(A), 1lb8(A), 1my2(A), 1p1q(A), 1p1u(A), 1p1w(A).
		13. Ligand: ACT × 5 Acetate ion PDB codes: 4n07(A), 4o3b(A), 5fhn(A), 6hcc(A).
		14. Ligand: PEG × 5 Di(hydroxyethyl)ether PDB codes: 4z0i(A), 5jei(A), 6faz(A), 6hc9(A), 6hcb(A).
_Cl		15. Metal: _CL × 5 PDB codes: 1nnk(A), 3pd9(A), 3tdj(A), 5elv(A), 6hca(A).
		16. Ligand: PO4 × 4 Phosphate ion PDB codes: 4yu0(A), 4z0i(A), 5jei(A).
		17. Ligand: BWD × 3 2-Amino-3-(5-Bromo-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin- 1-Yl)-Propionic acid PDB codes: 1mqh(A), 1mxu(A), 1my3(A).
		18. Ligand: CNI × 3 7-Nitro-2,3-Dioxo-2,3-Dihydroquinoxaline-6-Carbonitrile PDB codes: 3b7d(A), 3t9u(A), 3t9v(A).
		19. Ligand: DNQ × 3 6,7-Dinitroquinoxaline-2,3-Dione PDB codes: 1ftl(A), 1lb9(A), 4l17(A).
		20. Ligand: IWD × 3 2-Amino-3-(5-Iodo-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1- Yl)-Propionic acid PDB codes: 1mqg(A), 1my4(A), 3t96(B).
+ more. Press for full list

Cluster 3 contains 14 ligand types

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: NAG × 4 n-acetylglucosamine 2-Acetamido-2-Deoxy-Beta-D-Glucopyranose PDB codes: 3hsy(A), 3o2j(A), 5fwy(A), 5n6p(A).
		2. Ligand: GOL × 3 glycerin Glycerol PDB codes: 4u4s(A), 4u4x(A), 6hcc(A).
		3. Ligand: DMS × 1 dimethyl sulfoxide Dimethyl sulfoxide PDB code: 3pmx(A).
		4. Ligand: SO4 × 7 Sulfate ion PDB codes: 1wvj(A), 1xhy(A), 3hsy(B), 3pmv(A), 3tkd(A), 4iy5(A), 5ng9(A).
		5. Ligand: NAG-NAG × 5 NAG=2-Acetamido-2-Deoxy-Beta-D-Glucopyranose. PDB codes: 3h5v(A), 6njl(B), 6njn(B), 6qkz(B), 6u6i(C).
_Cl		6. Metal: _CL × 3 PDB codes: 4iy5(A), 5o9a(A), 6faz(A).
		7. Ligand: AJP × 2 Digitonin PDB codes: 5wel(A), 5wen(A).
		8. Ligand: NAG-NAG-BMA × 2 NAG=2-Acetamido-2-Deoxy-Beta-D-Glucopyranose, BMA=Beta-D-Mannopyranose. PDB codes: 6njm(B), 6u5s(A).
		9. Ligand: PG0 × 2 2-(2-Methoxyethoxy)ethanol PDB codes: 5jei(A), 5ns9(A).
		10. Ligand: 1PE × 1 Pentaethylene glycol PDB code: 5ns9(A).
		11. Ligand: ACT × 1 Acetate ion PDB code: 4n07(A).
		12. Ligand: ETE × 1 2-{2-[2-2-(Methoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethanol PDB code: 5jei(A).
		13. Ligand: PG4 × 1 Tetraethylene glycol PDB code: 4z0i(A).
_Li		14. Metal: _LI × 1 PDB code: 6q54(A).

Cluster 4 contains 6 ligand types

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: GYB × 1 (8r)-5-(4-Amino-3-Bromophenyl)-N,8-Dimethyl-8,9- Dihydro-2h,7h-[1,3]dioxolo[4,5- H][2,3]benzodiazepine- 7-Carboxamide PDB code: 5l1g(A).
		2. Ligand: GYD × 1 N~1~-{5-[(3-{[3-(D-Arginylamino)propyl]amino}propyl) amino]pentyl}-N~2~-[(2,4- Dihydroxyphenyl)acetyl]-D- Aspartamide PDB code: 6dm2(A).
		3. Ligand: GYY × 1 N-[3-({4-[(3-Aminopropyl)amino]butyl}amino)propyl]-2- (Naphthalen-1-Yl)acetamide PDB code: 6dm1(A).
		4. Ligand: GZD × 1 N,N,N-Trimethyl-5-({[(3s,5s,7s)-Tricyclo[3.3.1.1~3, 7~]decan-1-Yl]methyl}amino)pentan-1-Aminium PDB code: 6dm0(A).
		5. Ligand: LU7 × 1 N~1~-{5-[(3-{[3-(L-Arginylamino)propyl]amino}propyl) amino]pentyl}-N~2~-[(2,4- Dihydroxyphenyl)acetyl]-L- Aspartamide PDB code: 6o9g(A).
		6. Ligand: V8G × 1 Trans-4-Butylcyclohexane-1-Carboxylic acid PDB code: 6xsr(A).

Cluster 5 contains 4 ligand types

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: NAG × 32 n-acetylglucosamine 2-Acetamido-2-Deoxy-Beta-D-Glucopyranose PDB codes: 3hsy(B), 4u1w(A), 4u1x(A), 4u1y(A), 4u2p(A), 4u2q(A), 4u5b(A), 4u5c(A), 4u5d(A), 4u5e(A), 4u5f(A), 5fwx(A), 5fwy(A), 5kbs(A), 5kbt(A), 5kbu(A), 5kbv(A), 5l1b(A), 5l1e(A), 5l1f(A), 5l1g(A), 5l1h(A), 5n6p(A), 5vhw(A), 5vhx(A), 5vhy(A), 6njl(B), 6njm(B), 6njn(B), 6xsr(A).
		2. Ligand: NAG-NAG × 2 NAG=2-Acetamido-2-Deoxy-Beta-D-Glucopyranose. PDB codes: 4u4f(A), 6u5s(A).
		3. Ligand: NAG-NAG-BMA × 2 NAG=2-Acetamido-2-Deoxy-Beta-D-Glucopyranose, BMA=Beta-D-Mannopyranose. PDB codes: 3hsy(A), 6ruq(A).
		4. Ligand: NAG-NAG-BMA-BMA × 2 NAG=2-Acetamido-2-Deoxy-Beta-D-Glucopyranose, BMA=Beta-D-Mannopyranose. PDB codes: 3kg2(A), 4u4g(A).

Cluster 6 contains 4 ligand types

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: 6ZP × 1 perampanel 2-(6'-Oxo-1'-Phenyl[1',6'-Dihydro[2,3'-Bipyridine]]-5'- Yl)benzonitrile PDB code: 5l1f(A).
		2. Ligand: GYK × 2 (8r)-5-(4-Aminophenyl)-N,8-Dimethyl-8,9-Dihydro-2h,7h- [1,3]dioxolo[4,5-H][2,3]benzodiazepine-7- Carboxamide PDB codes: 5l1h(A), 6ruq(A).
		3. Ligand: 6ZQ × 1 3-(2-Chlorophenyl)-2-(2-{6-[(Diethylamino) methyl]pyridin-2-Yl}ethyl)-6-Fluoroquinazolin-4(3h)- One PDB code: 5l1e(A).
		4. Ligand: GYB × 1 (8r)-5-(4-Amino-3-Bromophenyl)-N,8-Dimethyl-8,9- Dihydro-2h,7h-[1,3]dioxolo[4,5- H][2,3]benzodiazepine- 7-Carboxamide PDB code: 5l1g(A).