Ligand clusters for UniProt code P11387

Ligand clusters for P11387: DNA topoisomerase 1 from Homo sapiens

		3 ligand clusters Cluster 1. 7 ligand types 8 ligands Cluster 2. 1 ligand type 2 ligands Cluster 3. 1 ligand type 1 ligand
Representative protein: 1sc7A

Structures

PDB		Schematic diagram
1sc7A
1t8iA
1tl8A
1k4tA
1rrjA
		more ...

Cluster 1 contains 7 ligand types

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Ligand		Description
		1. Ligand: TTC × 1 topotecan (S)-10-[(Dimethylamino)methyl]-4-Ethyl-4,9-Dihydroxy- 1h-Pyrano[3',4':6,7]inolizino[1,2-B]- Quinoline-3, 14(4h,12h)-Dione PDB code: 1k4t(A).
		2. Ligand: TTG-TTC × 2 TTG=2-(1-Dimethylaminomethyl-2-Hydroxy-8-Hydroxymethyl-9- Oxo-9,11-Dihydro-Indolizino[1,2-B]quinolin-7- Yl)-2- Hydroxy-Butyric acid, TTC=(S)-10-[(Dimethylamino)methyl]-4-Ethyl-4,9-Dihydroxy- 1h-Pyrano[3',4':6,7]inolizino[1,2-B]- Quinoline-3, 14(4h,12h)-Dione. PDB codes: 1rr8(C), 1rrj(A).
		3. Ligand: AI3 × 1 2,3-Dimethoxy-12h-[1,3]dioxolo[5,6]indeno[1,2- C]isoquinolin-6-Ium PDB code: 1tl8(A).
		4. Ligand: EHD × 1 4-Ethyl-4-Hydroxy-1,12-Dihydro-4h-2-Oxa-6,12a-Diaza- Dibenzo[b,H]fluorene-3,13-Dione PDB code: 1t8i(A).
		5. Ligand: M38 × 1 4-(5,11-Dioxo-5h-Indeno[1,2-C]isoquinolin-6(11h)-Yl) butanoate PDB code: 1sc7(A).
		6. Ligand: SA3 × 1 2,10-Dihydroxy-12-(Beta-D-Glucopyranosyl)-6,7,12,13- Tetrahydroindolo[2,3-A]pyrrolo[3,4- C]carbazole-5,7- Dione PDB code: 1seu(A).
		7. Ligand: TTG × 1 2-(1-Dimethylaminomethyl-2-Hydroxy-8-Hydroxymethyl-9- Oxo-9,11-Dihydro-Indolizino[1,2-B]quinolin-7- Yl)-2- Hydroxy-Butyric acid PDB code: 1k4t(A).

Cluster 2 contains 1 ligand type

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Ligand		Description
		1. Ligand: PG4 × 2 Tetraethylene glycol PDB codes: 1k4t(A), 1sc7(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
_Hg		1. Metal: _HG × 1 PDB code: 1k4t(A).