Ligand clusters for UniProt code P11309

Ligand clusters for P11309: Serine/threonine-protein kinase pim-1 from Homo sapiens

		Top 6 (of 27) ligand clusters Cluster 1. 175 ligand types 287 ligands Cluster 2. 7 ligand types 33 ligands Cluster 3. 5 ligand types 21 ligands Cluster 4. 3 ligand types 17 ligands Cluster 5. 3 ligand types 8 ligands Cluster 6. 3 ligand types 8 ligands
Representative protein: 1xr1A

Structures

PDB		Schematic diagram
1xr1A
5n4xA
3cy3A
3vbvA
5dhjA
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Cluster 1 contains 175 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: GOL × 19 glycerin Glycerol PDB codes: 2xiy(A), 3uix(A), 3umw(A), 4eny(A), 4ll5(A), 4lm5(A), 4lmu(A), 4n6z(A), 5n4v(A), 5o11(A), 5vua(B), 5vub(B), 5vuc(B), 6no9(A), 6vrv(A).
_Mg		2. Metal: _MG × 4 PDB codes: 1xr1(A), 3a99(A), 3f2a(A).
		3. Ligand: DMS × 2 dimethyl sulfoxide Dimethyl sulfoxide PDB codes: 2xiy(A), 4eny(A).
		4. Ligand: MIX × 2 mitoxantrone 1,4-Dihydroxy-5,8-Bis({2-[(2-Hydroxyethyl) amino]ethyl}amino)-9,10-Anthracenedione PDB codes: 4i41(A),
		5. Ligand: ADN × 1 adenosine Adenosine PDB code: 1yi4(A).
		6. Ligand: AMP × 1 Adenosine monophosphate PDB code: 1yxu(A).
		7. Ligand: ANP × 3 Phosphoaminophosphonic acid-Adenylate ester PDB codes: 1xr1(A), 1yxt(A), 2bzk(B).
		8. Ligand: EPE × 1 4-(2-Hydroxyethyl)-1-Piperazine ethanesulfonic acid PDB code: 2oi4(X).
		9. Ligand: STU × 1 Staurosporine PDB code: 1yhs(A).
		10. Ligand: LI6 × 1 3,4-Dihydroxy-1-Methylquinolin-2(1h)-One PDB code: 1yxv(A).
		11. Ligand: IMD × 12 Imidazole PDB codes: 1ywv(A), 1yxs(A), 1yxu(A), 1yxv(A), 1yxx(A), 2o3p(A), 2o63(A), 2o64(A), 2o65(A).
		12. Ligand: LY4 × 1 (9r)-9-[(Dimethylamino)methyl]-6,7,10,11-Tetrahydro-9h, 18h-5,21:12,17- Dimethenodibenzo[e,K]pyrrolo[3,4-H][1, 4,13]oxadiazacyclohexadecine-18,20-Dione PDB code: 2j2i(B).
		13. Ligand: EDO × 1 1,2-Ethanediol PDB code: 2oi4(X).
		14. Ligand: LY2 × 1 2-Morpholin-4-Yl-7-Phenyl-4h-Chromen-4-One PDB code: 1yi3(A).
		15. Ligand: VRV × 1 6-(5-Bromo-2-Hydroxyphenyl)-2-Oxo-4-Phenyl-1,2- Dihydropyridine-3-Carbonitrile PDB code: 2obj(A).
		16. Ligand: LI7 × 1 (3e)-3-[(4-Hydroxyphenyl)imino]-1h-Indol-2(3h)-One PDB code: 1yxx(A).
		17. Ligand: BI1 × 3 3-{1-[3-(Dimethylamino)propyl]-1h-Indol-3-Yl}-4-(1h- Indol-3-Yl)-1h-Pyrrole-2,5-Dione PDB codes: 1xws(A), 2bik(B), 2bil(B).
		18. Ligand: IYZ × 1 1-(3-{6-[(Cyclopropylmethyl)amino]imidazo[1,2- B]pyridazin-3-Yl}phenyl)ethanone PDB code: 2c3i(B).
		19. Ligand: DW2 × 1 Ru-Pyridocarbazole-2 PDB code: 2bzi(B).
		20. Ligand: HB1 × 1 Ruthenium-Pyridocarbazole-1 PDB code: 2bzh(B).
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Cluster 2 contains 7 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 4lm5(A).
		2. Ligand: IMD × 1 Imidazole PDB code: 2o63(A).
		3. Ligand: EDO × 13 1,2-Ethanediol PDB codes: 3cy2(A), 5kgd(A), 5kge(A), 5kgg(A), 5kgi(A), 5kgk(A), 6bsk(A).
		4. Ligand: SO4 × 11 Sulfate ion PDB codes: 2j2i(B), 3bwf(A), 3we8(A), 4dtk(A), 5kgd(A), 5kge(A), 5kgg(A), 5kgi(A), 5kgk(A), 6bsk(A), 6pdp(A).
		5. Ligand: ACT × 4 Acetate ion PDB codes: 4a7c(A), 5kcx(A), 6vru(A), 6ykd(A).
		6. Ligand: IMD × 2 Imidazole PDB codes: 3vby(A), 4alw(A).
		7. Ligand: PO4 × 1 Phosphate ion PDB code: 5v80(A).

Cluster 3 contains 5 ligand types

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Ligand		Description
		1. Ligand: GOL × 3 glycerin Glycerol PDB codes: 4mta(A), 6pcw(A), 6pdi(A).
		2. Ligand: EDO × 1 1,2-Ethanediol PDB code: 2bzh(B).
		3. Ligand: PO4 × 10 Phosphate ion PDB codes: 4enx(A), 4eny(A), 4k0y(A), 4k18(A), 4k1b(A), 5dgz(A), 5dhj(A), 5vua(B), 6no8(A), 6no9(A).
		4. Ligand: EDO × 3 1,2-Ethanediol PDB codes: 4dtk(A), 5kgg(A), 6pdi(A).
		5. Ligand: SO4 × 4 Sulfate ion PDB codes: 1xws(A), 3uix(A), 3umw(A), 3umx(A).

Cluster 4 contains 3 ligand types

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Ligand		Description
		1. Ligand: GOL × 9 glycerin Glycerol PDB codes: 4ll5(A), 4wrs(A), 4wsy(A), 4wt6(A), 5eol(A), 5ipj(A), 6mt0(A), 6pcw(A), 6pdi(A).
		2. Ligand: SO4 × 6 Sulfate ion PDB codes: 5kgd(A), 5kge(A), 5kgg(A), 5kgi(A), 5kgk(A), 6bsk(A).
		3. Ligand: EDO × 2 1,2-Ethanediol PDB codes: 4dtk(A), 4gw8(A).

Cluster 5 contains 3 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 6ykd(A).
		2. Ligand: EDO × 6 1,2-Ethanediol PDB codes: 4dtk(A), 5kgd(A), 5kge(A), 5kgg(A), 5kgi(A), 6bsk(A).
		3. Ligand: IMD × 1 Imidazole PDB code: 5o13(A).

Cluster 6 contains 3 ligand types

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Ligand		Description
		1. Ligand: GOL × 6 glycerin Glycerol PDB codes: 4ty1(A), 4wrs(A), 5eol(A), 5ipj(A), 5o11(A), 6mt0(A).
		2. Ligand: EDO × 1 1,2-Ethanediol PDB code: 5kgg(A).
		3. Ligand: SO4 × 1 Sulfate ion PDB code: 4dtk(A).