Ligand clusters for UniProt code P06730

Ligand clusters for P06730: Eukaryotic translation initiation factor 4E from Homo sapiens

		Top 6 (of 18) ligand clusters Cluster 1. 16 ligand types 31 ligands Cluster 2. 3 ligand types 3 ligands Cluster 3. 2 ligand types 2 ligands Cluster 4. 3 ligand types 4 ligands Cluster 5. 2 ligand types 4 ligands Cluster 6. 2 ligand types 4 ligands
Representative protein: 1ipbA

Structures

PDB		Schematic diagram
1ipbA
1ipcA
1wkwA
2w97A
5zk5A
		more ...

Cluster 1 contains 16 ligand types

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Ligand		Description
		1. Ligand: GOL × 3 glycerin Glycerol PDB codes: 2w97(B), 5gw6(A),
		2. Ligand: MGP × 7 7-Methyl-Guanosine-5'-Triphosphate PDB codes: 1ipc(A), 3am7(A), 4tpw(A), 5t46(A), 5zjy(A), 5zk9(A), 7meu(A).
		3. Ligand: MGO × 4 [[(2r,3s,4r,5r)-5-(6-Amino-3-Methyl-4-Oxo-5h- Imidazo[4,5-C]pyridin-1-Yl)-3,4-Dihydroxy- Oxolan-2- Yl]methoxy-Hydroxy-Phosphoryl] phosphono hydrogen phosphate PDB codes: 2v8w(A), 2w97(A), 4aza(A).
		4. Ligand: MGT × 4 7n-Methyl-8-Hydroguanosine-5'-Triphosphate PDB codes: 4tqb(A), 5zjz(A), 5zk5(A), 5zk7(A).
		5. Ligand: GTA × 2 P1-7-Methylguanosine-P3-Adenosine-5',5'-Triphosphate PDB codes: 1ipb(A), 1wkw(A).
		6. Ligand: 5NX × 1 3-[[(2~{r},3~{s},4~{r},5~{r})-5-[2-Azanyl-7-[(3- Chlorophenyl)methyl]-6-Oxidanylidene-1~{h}-Purin- 7- Ium-9-Yl]-3,4-Bis(oxidanyl)oxolan-2-Yl]methylamino]-4- Oxidanyl-Cyclobut-3-Ene-1,2-Dione PDB code: 5ehc(A).
		7. Ligand: 5O8 × 1 ~{N}-[[(2~{r},3~{s},4~{r},5~{r})-5-[2-Azanyl-6- Oxidanylidene-7-(Phenylmethyl)-1~{h}-Purin-7-Ium-9- Yl]-3,4-Bis(oxidanyl)oxolan-2-Yl]methyl]-1,1,1- Tris(fluoranyl)methanesulfonamide PDB code: 5ei3(A).
		8. Ligand: 5O8-SO4 × 1 5O8=~{N}-[[(2~{r},3~{s},4~{r},5~{r})-5-[2-Azanyl-6- Oxidanylidene-7-(Phenylmethyl)-1~{h}-Purin-7-Ium-9- Yl]-3,4-Bis(oxidanyl)oxolan-2-Yl]methyl]-1,1,1- Tris(fluoranyl)methanesulfonamide, SO4=Sulfate ion. PDB code: 5eir(A).
		9. Ligand: 5PQ × 1 3-[[(2~{r},3~{s},4~{r},5~{r})-5-(2-Azanyl-7-Methyl-6- Oxidanylidene-1~{h}-Purin-7-Ium-9-Yl)-3,4- Bis(oxidanyl)oxolan-2-Yl]methylamino]-4-Oxidanyl- Cyclobut-3-Ene-1,2-Dione PDB code: 5ekv(A).
		10. Ligand: 6LI × 1 7-[2-(4-Chlorophenoxy)ethyl]guanosine 5'-(Dihydrogen phosphate) PDB code: 4dt6(A).
		11. Ligand: EDO × 1 1,2-Ethanediol PDB code: 5zml(A).
		12. Ligand: HLI × 1 (4-{7-[2-(4-Chlorophenoxy)ethyl]-2-(Methylamino)-6-Oxo- 6,7-Dihydro-1h-Purin-8- Yl}phenyl)phosphonic acid PDB code: 4dum(A).
		13. Ligand: M7G × 1 7n-Methyl-8-Hydroguanosine-5'-Diphosphate PDB code: 4tqc(A).
		14. Ligand: MGQ × 1 7-Benzyl guanine monophosphate PDB code: 2v8x(A).
		15. Ligand: MGV × 1 P-Fluoro-7-Benzyl guanine monophosphate PDB code: 2v8y(A).
		16. Ligand: SO4 × 1 Sulfate ion PDB code: 5ei3(A).

Cluster 2 contains 3 ligand types

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Ligand		Description
		1. Ligand: 33R × 1 (2e)-2-{2-[4-(3,4-Dichlorophenyl)-1,3-Thiazol-2- Yl]hydrazinylidene}-3-(2- Nitrophenyl)propanoic acid PDB code: 4tpw(A).
		2. Ligand: 34J × 1 (2s)-3-(4-Amino-3-Nitrophenyl)-2-{2-[4-(3,4- Dichlorophenyl)-1,3-Thiazol-2- Yl]hydrazinyl}propanoic acid PDB code: 4tqc(A).
		3. Ligand: 34K × 1 (2e)-2-{2-[4-(4-Bromophenyl)-1,3-Thiazol-2- Yl]hydrazinylidene}-3-(2-Nitrophenyl)propanoic acid PDB code: 4tqb(A).

Cluster 3 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 5zk7(A).
		2. Ligand: Z5D × 1 (2e)-2-{2-[4-([1,1'-Biphenyl]-4-Yl)-1,3-Thiazol-2- Yl]hydrazinylidene}-3-(2- Nitrophenyl)propanoic acid PDB code: 7meu(A).

Cluster 4 contains 3 ligand types

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Ligand		Description
		1. Ligand: GOL × 2 glycerin Glycerol PDB codes: 2w97(A), 5gw6(A).
		2. Ligand: EDO × 1 1,2-Ethanediol PDB code: 5zml(A).
		3. Ligand: PEG × 1 Di(hydroxyethyl)ether PDB code: 5zk9(A).

Cluster 5 contains 2 ligand types

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Ligand		Description
		1. Ligand: EDO × 2 1,2-Ethanediol PDB codes: 4dt6(A), 4dum(A).
		2. Ligand: MES × 2 2-(N-Morpholino)-Ethanesulfonic acid PDB codes: 4tpw(A), 4tqb(A).

Cluster 6 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 5t46(A).
		2. Ligand: SO4 × 3 Sulfate ion PDB codes: 2w97(A), 3u7x(A).