Ligand clusters for UniProt code O76074

Ligand clusters for O76074: cGMP-specific 3',5'-cyclic phosphodiesterase from Homo sapiens

		Top 6 (of 10) ligand clusters Cluster 1. 33 ligand types 107 ligands Cluster 2. 1 ligand type 1 ligand Cluster 3. 1 ligand type 1 ligand Cluster 4. 1 ligand type 1 ligand Cluster 5. 1 ligand type 1 ligand Cluster 6. 1 ligand type 1 ligand
Representative protein: 1t9sA

Structures

PDB		Schematic diagram
1t9sA
3jwqA
6l6eA
3jwrA
1uduA
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Cluster 1 contains 33 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: 5GP × 1 Guanosine-5'-Monophosphate PDB code: 1t9s(A).
_Zn		2. Metal: _ZN × 35 PDB codes: 1rkp(A), 1t9r(A), 1t9s(A), 1tbf(A), 1udt(A), 1udu(A), 1uho(A), 1xoz(A), 1xp0(A), 2chm(A), 2h40(A), 2h42(A), 2h44(A), 3bjc(A), 3hc8(A), 3hdz(A), 3jwq(A), 3jwr(A), 3shy(A), 3shz(A), 3tge(A), 3tgg(A), 4g2w(A), 4g2y(A), 4i9z(A), 4ia0(A), 4md6(A), 4oew(A), 4oex(A), 5jo3(B), 5zz2(A), 6acb(A), 6iwi(A), 6l6e(A).
_Mg		3. Metal: _MG × 30 PDB codes: 1rkp(A), 1t9s(A), 1tbf(A), 1udt(A), 1udu(A), 1uho(A), 1xoz(A), 1xp0(A), 2chm(A), 2h40(A), 2h42(A), 2h44(A), 3bjc(A), 3hc8(A), 3hdz(A), 3jwq(A), 3jwr(A), 3shy(A), 3shz(A), 3tge(A), 3tgg(A), 4g2w(A), 4g2y(A), 4i9z(A), 4ia0(A), 4md6(A), 4oew(A), 4oex(A), 5zz2(A), 6acb(A).
		4. Ligand: VIA × 4 sildenafil 5-{2-Ethoxy-5-[(4-Methylpiperazin-1-Yl) sulfonyl]phenyl}-1-Methyl-3-Propyl-1h,6h,7h- Pyrazolo[4,3- D]pyrimidin-7-One PDB codes: 1tbf(A), 1udt(A), 2h42(A), 3jwq(A).
		5. Ligand: VDN × 3 vardenafil 2-{2-Ethoxy-5-[(4-Ethylpiperazin-1-Yl) sulfonyl]phenyl}-5-Methyl-7-Propylimidazo[5,1- F][1,2, 4]triazin-4(1h)-One PDB codes: 1uho(A), 1xp0(A), 3b2r(A).
		6. Ligand: E6L × 1 avanafil 4-[(3-Chloranyl-4-Methoxy-Phenyl)methylamino]-2-[(2s)- 2-(Hydroxymethyl)pyrrolidin-1-Yl]-N- (Pyrimidin-2- Ylmethyl)pyrimid ine-5-Carboxamide PDB code: 6l6e(A).
		7. Ligand: IBM × 1 3-Isobutyl-1-Methylxanthine PDB code: 1rkp(A).
		8. Ligand: PO4 × 1 Phosphate ion PDB code: 1t9r(A).
		9. Ligand: 7CA × 1 5,7-Dihydroxy-2-(4-Methoxyphenyl)-8-(3-Methylbutyl)-4- Oxo-4h-Chromen-3-Yl 6-Deoxy-Alpha-L- Mannopyranoside PDB code: 2h44(A).
		10. Ligand: 3P4 × 1 5-[2-(But-3-En-1-Yloxy)-5-(1-Hydroxyvinyl)pyridin-3- Yl]-3-Ethyl-2-(1-Ethylazetidin-3-Yl)-1,2,6,7a- Tetrahydro-7h-Pyrazolo[4,3-D]pyrimidin-7-One PDB code: 2chm(A).
		11. Ligand: CIA × 2 6-Benzo[1,3]dioxol-5-Yl-2-Methyl-2,3,6,7,12,12a- Hexahydro-Pyrazino[1',2':1,6]pyrido[3,4-B]indole- 1,4- Dione PDB codes: 1udu(A), 1xoz(A).
		12. Ligand: SO4 × 4 Sulfate ion PDB codes: 4md6(A), 5zz2(A), 6acb(A), 6l6e(A).
		13. Ligand: PEG × 3 Di(hydroxyethyl)ether PDB codes: 4g2w(A), 4g2y(A), 4i9z(A).
		14. Ligand: IBM × 1 3-Isobutyl-1-Methylxanthine PDB code: 3jwr(A).
		15. Ligand: 0H3 × 1 7-(6-Methoxypyridin-3-Yl)-4-{[2-(Propan-2-Yloxy) ethyl]amino}-1-(2-Propoxyethyl)pyrido[4,3- D]pyrimidin- 2(1h)-One PDB code: 3tgg(A).
		16. Ligand: 24E × 1 3-(4-Hydroxybenzyl)-1-(Thiophen-2-Yl)chromeno[2,3- C]pyrrol-9(2h)-One PDB code: 4md6(A).
		17. Ligand: 5BA × 1 5-Bromo-2-{5-[(4-Methylpiperazin-1-Yl)acetyl]-2- Propoxyphenyl}-6-(Propan-2-Yl)pyrimidin-4(3h)-One PDB code: 4i9z(A).
		18. Ligand: 5BB × 1 5-Bromo-2-{2-Ethoxy-5-[(4-Methylpiperazin-1-Yl) sulfonyl]phenyl}-6-Octylpyrimidin-4(3h)-One PDB code: 4ia0(A).
		19. Ligand: 5BO × 1 5-Bromo-6-Ethyl-2-{5-[(4-Methylpiperazin-1-Yl) sulfonyl]-2-Propoxyphenyl}pyrimidin-4(3h)-One PDB code: 3sie(A).
		20. Ligand: 5CO × 1 5-Chloro-6-Ethyl-2-{5-[(4-Methylpiperazin-1-Yl) sulfonyl]-2-Propoxyphenyl}pyrimidin-4(3h)-One PDB code: 3shz(A).
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Cluster 2 contains 1 ligand type

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Ligand		Description
		1. Ligand: VIA × 1 sildenafil 5-{2-Ethoxy-5-[(4-Methylpiperazin-1-Yl) sulfonyl]phenyl}-1-Methyl-3-Propyl-1h,6h,7h- Pyrazolo[4,3- D]pyrimidin-7-One PDB code: 3jwq(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: FZA × 1 (13bs)-4,9-Dimethoxy-14-Methyl-8,13,13b,14- Tetrahydroindolo[2',3':3,4]pyrido[2,1-B]quinazolin- 5(7h)-One PDB code: 6vbi(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: IBM × 1 3-Isobutyl-1-Methylxanthine PDB code: 3jwr(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: IBM × 1 3-Isobutyl-1-Methylxanthine PDB code: 3jwr(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
		1. Ligand: CIT × 1 citric acid Citric acid PDB code: 1t9r(A).