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Figure 4.
Fig. 4. A model for the ICAM-1 dimer on the cell surface.
Domains 1 and 2 and their orientation in the dimer are from the
crystal structure. The rod-like shape of domains 1-5 in the
monomer and the bend between domains 3 and 4 are from electron
microscopy (3, 36). Dimerization or proximity between domain 5
is based on hindrance of antibody binding to this domain in the
dimer (25), and association at the transmembrane domain is based
on its role in dimerization (24, 25).
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