Figure 1 - full size

Figure 1. Figure 1. Par-6 is conserved in evolution. (a) Full-length hPar-6 and the 2HP-4 clone (hPar-2HP) are shown schematically. CRIB, Cdc42/Rac interactive binding motif; PDZ, PDZ domain. The residue numbers indicate the approximate limits of each domain. (b) Tissue distribution of hPar-6 mRNA. The size markers (in kb) are shown at the left. The blot was also probed with actin cDNA as an RNA loading control (bottom panel). (c) Sequence alignments of Par-6 from C. elegans (cPar-6), Drosophila (dPar-6), Xenopus (xPar-6), mouse (mPar-6) and human (hPar-6), and clone CAB44747. The sequences corresponding to the CRIB motif in hPar-6 are boxed and those corresponding to the PDZ domain are underlined.