Figure 4 - full size

Figure 4.
Fig. 4. Interactions between the indole ring of U-90152 and Pro-236. U-90152 is shown with thick bonds, residues 235-237 with thin bonds and interatomic distances <3.6 Å by broken lines. With so many interactions it is not surprising that mutations of this residue (such as Pro-236-Leu) disrupt the binding of BHAPs.