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Figure 4.
Figure 4. The DHODA dimer structure viewed from above the
twofold axis. The orientation of subunit A is the same as that
of Figure 3. Secondary structure elements are coloured according
to B factor: residues with B factors below 20 Å2 are dark blue
and residues with B factors above 40 Å2 are bright red. The
three cavities inside the dimer are shown as probe occupied
volumes, as calculated by the program VOIDOO [40] using a probe
radius of 1.2 Å. The two cavities above the flavin molecules are
coloured magenta, while the intersubunit void is shown in
orange. The two water molecules inside the central void are
shown as green spheres. The intersubunit Glu206-Lys296 salt
bridges are shown in ball-and-stick representation. (Figure
produced using the programs BOBSCRIPT and RASTER3D.)
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