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Figure 5.
Fig. 5. Structural basis for nucleotide binding by human
pol  . The
nucleotide binding pocket of human pol  (A) is
compared with the putative (modeled) nucleotide binding pocket
of human pol (B). The
incoming ddCTP (red) is shown, hydrogen bonded to its templating
base (light yellow). Relevant residues are shown (ball and
stick), and their position relative to the N terminus of the
protein is indicated. One of the most striking differences
between the pol and pol
dNTP
binding site is the nonconservation of pol residue
Asp276 (green), which plays a direct role in dNTP binding and
selectivity (for details, see "Discussion"). A model structure
of the whole -core of
human pol , with the
exception of  -helix A,
was generated with the program Swiss Model
(www.expasy.ch/swissmod/swiss-model.html). The figure was made
with Swiss PDB Viewer ((42) www.expasy.ch/spdbv/) and rendered
with POV Ray (www.povray.org).
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