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Figure 4.
Figure 4 Subdomain structures of the radixin FERM domain. The
color codes used are light green for radixin subdomains, light
blue for ubiquitin, yellow for acyl-coenzyme A binding protein,
red for the PTB domain and orange for the PH domain. (A)
Superimposition of radixin subdomain A on ubiquitin (PDB code
1UBI, blue). (B) Superimposition of radixin subdomain B on
E.coli acyl-coenzyme A binding protein (yellow, 1ACA). (C)
Superimposition of radixin subdomain C on the IRS-1 PTB domain
(1QQG, red). (D) Superimposition of radixin subdomain C on the
PH domain (1PLS, orange). (E) Comparison of the IP3-binding
sites found in the radixin FERM domain (left), the phospholipase
C  1
PH domain (middle) and the  -spectrin
PH domain (right). Two loops forming the binding site of each PH
domain are colored in blue. The binding site of the radixin FERM
domain is located at the basic cleft between subdomains A (a
ubiquitin-like fold in light green) and C (a PTB-like fold in
light blue) (see text). The N-terminal half of helix  1C
of subdomain C and the protruding loop between strands 3A
and 5A
of subdomain A form the IP3-binding site of the radixin FERM
domain and are colored in blue.
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