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Figure 2.
Figure 2. (a) Stereoview of difference Fourier maps showing the
fit of α-APA into the electron density. The α-APA coordinates
correspond to the current refined model. The green map is the
difference Fourier map at 3.5 å resolution between the
HIV-1 RT/α-APA R 95845 (dibrominated) complex and the HIV-1
RT/α-APA R 90385 (dichlorinated) complex contoured at a 10σ
level which revealed the positions of two bromine atoms. The
blue map is the mF[o]–F[c] difference Fourier map at 3.0
å resolution calculated from a model before α-APA was
included in the refinement; the phases were computed from the
back-transformation of electron density averaged from three
HIV-1 RT/inhibitor complexes; the map is contoured at 1.5σ. (b)
Stereoview of a portion of a 2mF[o]–F[c] difference Fourier
map at 2.8 å resolution in the region around the
non-nucleoside inhibitor-binding pocket showing the α-APA
inhibitor and some of the nearby amino acid residues. The phases
were computed from the current atomic model (R=0.255) and the
map is contoured at 1.2σ. Figure 2. (a) Stereoview of
difference Fourier maps showing the fit of α-APA into the
electron density. The α-APA coordinates correspond to the
current refined model. The green map is the difference Fourier
map at 3.5 å resolution between the HIV-1 RT/α-APA R
95845 (dibrominated) complex and the HIV-1 RT/α-APA R 90385
(dichlorinated) complex contoured at a 10σ level which revealed
the positions of two bromine atoms. The blue map is the
mF[o]–F[c] difference Fourier map at 3.0 å resolution
calculated from a model before α-APA was included in the
refinement; the phases were computed from the
back-transformation of electron density averaged from three
HIV-1 RT/inhibitor complexes; the map is contoured at 1.5σ. (b)
Stereoview of a portion of a 2mF[o]–F[c] difference Fourier
map at 2.8 å resolution in the region around the
non-nucleoside inhibitor-binding pocket showing the α-APA
inhibitor and some of the nearby amino acid residues. The phases
were computed from the current atomic model (R=0.255) and the
map is contoured at 1.2σ.
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