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Figure 1.
Fig. 1. IB1 differs from JIP-1 by the insertion of 47
amino acids, which contain a HLH and PID domain. A, schematic
diagram of IB1 and JIP1 with the putative motifs (HLH = helix
loop helix; PID = phosphotyrosine interaction domain; NTS =
nuclear translocation signal). B, amino acid sequence comparison
of IB1 with other bHLH proteins (31-34). Shaded amino acids are
conserved in at least five of the sequences represented. C,
sequence alignments of the^ PID domain of IB1 with several
members of PID-containing proteins (35-39). Shaded amino acids
are conserved in at least five of the^ sequences represented
(27).
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