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Figure 1.
Fig. 1. Multiple amino acid alignment of human and mouse
orthologs of pol  with
human pol  . Numbers
indicate the amino acid position relative to the N terminus of
each DNA polymerase. Invariant residues in the three enzymes
aligned are indicated in white letters over a black background.
Other amino acid identities with respect to human pol sequence
are indicated in bold letters. Amino acids 36-126 (human pol
) and
35-125 (murine pol (20)) are
predicted to form a BRCT domain (light gray). Amino acids
241-575 (human pol ) and
239-573 (murine pol (20))
form a conserved -core,
including an 8-kDa domain (gray) and a 31-kDa polymerization
domain (dark gray). The 23 amino acid residues that are
invariant among all family X DNA polymerases (34) are indicated
by an asterisk at the top of the alignment.
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