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Figure 7.
Figure 7 Schematic representation of the pre-incision complex
formed between UvrBC and damaged DNA. With the early
participation of UvrA, the damaged DNA is unwound around the
adduct, and an open DNA structure forms with UvrBC proteins,
which is characterized by 2 unpaired bases 5' and 3 unpaired
bases 3' to the adduct. The 3' and 5' double-stranded nuclease
activities of UvrBC incise the damage 1 base 3' and 6 bases 5'
to the open structure, respectively. In addition, we propose a
direct interaction between the UvrBC and the adducted base. The
yellow, violet, green and blue colored sticks in the DNA strands
represent the bases cytosine, thymine, adenine and guanine,
respectively. The red stick represents the adducted guanine.
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