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Figure 6.
Figure 6 Stereo view images of the novel channel opened by Ca^2+
ion binding in site 3. Protein domains are colored as in Figure
3. (A) On one side, the electrostatic surface potential (black
transparent) shows that the active site triad residues Cys272,
His330 and Asp353 are buried and inaccessible. The movement of
the loop bearing residues Asp320−Ser325 opens the channel in
the activated TGase 3, and exposes the side chains of the Trp236
and Trp327 residues. (B) On the opposite side, the guanidinium
group of Arg396 has moved to form a salt bridge with Glu586,
allowing the hole to extend through the protein.
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