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Figure 5.
Figure 5 Models of the interactions of RIM2  with
Munc13-1 and Rab3A. RIM NT: -RIM
N-terminal sequence; Munc13 NT: Munc13-1 N-terminal sequence;
ZF: -RIM
ZF domain. The positions of the two -helices
(a1 and 2) and the SGAWFY motif are modeled according to the
crystal structure of the rabphilin/Rab3A complex (Ostermeier and
Brunger, 1999). Note that the helices may not be completely
structured in the absence of Rab3A. A star indicates the
approximate location of the mutation that disrupts Munc13-1
binding.
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