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Figure 4.
Fig. 4. The putative substrate-binding site. A, the two
acetate-binding sites in the active site cavity (Act1 and Act2).
Residues surrounded the binding site are displayed as
ball-and-stick representations and the zinc ion as a purple
sphere. B, the proposed substrate-binding site with the modeled
N-acetyl-D-methionine in ball-and-stick and the active water
molecule (Wat) as a green sphere. The oxygen atoms of the
acetates and substrate are expected to bind at the same position
because of the extensive interactions. The first acetate may
displace the attacking water molecule at the metal center.
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