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Figure 4.
Fig. 4. Proposed model of the gelsolin-two-actin complex.
Schematic representations of two copies of the G4-G6-actin
complex are oriented so that the actin protomers are related
according to the Holmes model of the actin filament (9).
Gelsolin domains G4, G5, and G6 bound to actin protomer 1 are
labeled G1, G2, and G3, respectively. The actin filament is
oriented to run vertically in the plane of the paper, indicated
by the arrow (cyan) as in Fig. 1A. The COOH-terminus of G3
(labeled C) and the NH[2]-terminus of G4 (labeled N) are 66
Å apart in this model.
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