Figure 4.
Figure 4 Model of phospholipid headgroup interactions with
PI3K .
a, Orthogonal views of the solvent-accessible surface. The
activation loop is black. An inositol 1,4,5-trisphosphate
(InsP[3]) molecule (white ball-and-stick) is modelled in the
active site with the 3-OH near the -phosphate
of the bound ATP. b, The same views in ribbon representation
showing the activation loop (magenta) and InsP[3] (blue). The
right panel is expanded to show features of the putative
headgroup interaction.
.
a, Orthogonal views of the solvent-accessible surface. The
activation loop is black. An inositol 1,4,5-trisphosphate
(InsP[3]) molecule (white ball-and-stick) is modelled in the
active site with the 3-OH near the