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Figure 3.
Figure 3. Protomer views and schematic. (a,b) Orthogonal
views of the p97/VCP protomer with subdomains colored as in
Figure 1a. The disordered connection between  12'
and 13'
is indicated as a dashed green line. Selected helices are
labeled. (c) Schematic models of the p97/VCP protomer in the ADP
-AlF[x] and ADP states colored according to subdomain. The model
of the ADP state is derived from the comparison of the p97/VCP
crystal structure with the cryo-EM map of the ADP state^27; in
the ADP state the N-terminal domain is highly mobile and the
protrusion following helix 12'
of the D2 helical domain becomes ordered.
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