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Figure 3.
Figure 3. Stereo-diagram comparing the NNRTI binding sites
of wild-type and Tyr181Cys mutant RTs for the following
complexes: (a) nevirapine, (b) TNK-651, (c) PETT-2, and (d)
efavirenz. The thinner bonds show the main-chain backbone with
wild-type RT coloured as dark grey and the mutant RT as light
grey. Side-chains and the inhibitors are shown with thicker
bonds with wild-type RT coloured brown and mutant RT as green.
For clarity the side-chain of 181 and inhibitor are shown in red
for wild-type RT and in cyan for the mutant. The broken yellow
lines represent hydrogen bonds.
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