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Figure 3.
Figure 3. A comparison of E. coli EF-Tu-GDP and T.
thermophilus EF-Tu-GTP. The polypeptide backbone is shown in
blue, except as noted: the Switch I region, in yellow; the
Switch II region, in orange; the GDP or GTP molecule, in red;
and Mg2+ ions, in magenta. The standard view of EF-Tu from E.
coli (a) and T. thermophilus (b), comparing the GDP form (a) to
the GTP form (b). The view illustrates the major differences in
the relative rearrangement of the domains between the GDP and
GTP forms as well as the local conformational differences
between the Switch I and II regions. A side view of EF-Tu, from
E. coli (c) and T. thermophilus (d), indicates the regions of
interaction between the Switch I tip of the GDP form, shown in
(c), and Domain 3. The analogous region in the Switch I sequence
of EF-Tu-GTP does not interact with Domain 3. (The figure has
been generated by MOLSCRIPT [29].)
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