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Figure 2.
Figure 2. p97/VCP protomer and pore schematic. (a,b) Two
orthogonal views of molecular surfaces of the p97/VCP hexamer,
with the subdomains of alternate protomers colored red or as in
Figure 1a. The Zn2+ and the putative His317 ligands are shown in
the central pore. Molecular dimensions are based on C  -C
distances,
with radii shown for the top view and diameters given for the
side view at the narrowest region in the middle and as well as
between opposing helices 12'.
(c) Schematic view of the pore with dimensions as indicated. The
protrusions shown within the D2 region of the pore indicate the
presence of a disordered section of the protein (residues 586
-597) that may point into the central pore. (d)
Protomer-protomer interactions. The 'A-facing' elements are
colored and labeled in red, the 'B-facing' elements are colored
according to subdomain. The view has been selected to highlight
the 'wrap-around' interaction involving helix 5/
5'.
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