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Figure 2.
Fig. 2. X-ray crystal structure of the PPAR  LBD. (A)
The PPAR protein is
displayed as a red worm with the AF2 helix in red and K292 in
dark blue. The LxxLL peptide is displayed as a purple worm. The
agonist ligand GW409544 is displayed in space-filling
representation colored by atom type. The solvent-accessible
ligand binding pocket is shown as a white dot surface. Helices
2, 2', 3, 9, and 10 are indicated. The amino acids Phe-273,
Lys-292, Tyr-314, Glu-462, and Tyr-464 are displayed in light
blue. (B) A 2F[o]  F[c] omit
map showing the electron density (1  ) of the
ligand and the surrounding residues. (C) Key hydrogen bonding
(yellow line) and hydrophobic (white broken line) interactions
between GW409544 and the PPAR protein and
a bound water molecule.
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