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Figure 2.
Fig. 2. Active site superposition of open and closed BF
structures. (A) The 11-bp open binary complex (yellow) and the
closed ternary complex (blue) are shown in stereo view. The
largest conformational differences occur in the fingers domain,
including the O helix, O1 helix, and preinsertion site. The
acceptor template base (n) occupies the preinsertion site in the
open conformation and the insertion site in the closed
conformation. (B) A close-up view of the preinsertion site. The
locations of the conserved Tyr-714 are indicated.
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