|
Figure 1.
Figure 1. Heavy chain CDR residues selected for
diversification in phage-displayed libraries. (a) The backbones
of the humanized 4D5 V[H] and V[L] domains are shown as grey or
pink tubes, respectively. The side-chains of CDR residues
included in the library diversification strategy are shown, and
the residues are colored yellow (CDR-H1), green (CDR-H2) or blue
(CDR-H3). b, CPK representation of a. Residues are numbered
according to the nomenclature described by Kabat et al.[52.]
This Figure was generated with Insight II (Accelrys, San Diego)
using coordinates for the crystal structure of free Fv4D5 (PDB
entry 1FVC). [16.]
|
