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Figure 1.
Fig. 1. Ribbon representation of two GpIb  -thrombin
complexes related by crystal symmetry. The asymmetric unit
contains one molecule of GpIb and one molecule
of thrombin, which associate as a crystallographically
independent complex. GpIb is colored green,
except for the anionic region (Asp269 to sTyr279), which is in
red, and a region corresponding to peptide Phe^216 to Thr240 is
in gold. The thrombin heavy chain is colored light blue, with
exosite I (Lys21 to Gln24, Tyr71 to Asn74, and Lys106 to Lys107)
and exosite II (Arg98, Arg123, and Arg245 to Lys252) colored
dark blue (numbering for thrombin used here starts at the first
residue of the mature heavy chain of human thrombin, and
addition of 363 converts the numbering to that of prothrombin;
see supporting online text for chymotrypsin numbering). The
thrombin light chain (residues 1 to 29) is in gray.
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