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Figure 1.
Figure 1. Binding interactions and sequence relationships of Eph
receptors and ephrins. Yellow and purple indicate high
binding affinity to partners of the A or B subclass,
respectively; yellow with a purple center indicates high binding
affinity to partners of the A subclass and lower binding
affinity to partners of the B subclass; and purple with a yellow
center indicates high binding affinity to partners of the B
subclass and lower binding affinity to partners of the A
subclass. The question mark indicates that the binding
preference of the EphA10 receptor^15 has not yet been
determined. Eph receptors and ephrins are arranged according to
the phylogenetic trees determined using the Clustal program. The
dendrogram for the Eph receptors was constructed using the
sequences of the ephrin-binding domains^5 of the human Eph
receptors, and the dendrogram for the ephrins was constructed
using the sequences of the Eph receptor-binding domains^5 of the
human ephrins. The lengths of the horizontal branches are
proportional to sequence divergence between proteins and the
arrangement of the branches indicates putative phylogenetic
relationships. EphA9, EphB5 and ephrin-A6 are not shown because
these proteins were identified in chicken and do not appear to
be present in the human and mouse genomes.
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