Figure 1 - full size

Figure 1.
Fig. 1. LoxP, the natural recombination site of Cre. The outermost 13-bp regions on each side (black) are inverted repeats. The middle region (gray) is asymmetric and confers directionality to the site. The base pair identities most important for Cre binding (12) are boxed. Arrows indicate sites of cleavage during recombination.