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Figure 1.
Figure 1 Overall structure of PI3K  .
a, Ribbon diagram of PI3K (prepared
with MOLSCRIPT31) showing the four domains: RBD (magenta), C2
(blue), helical (green) and catalytic with N-lobe (red) and
C-lobe (yellow). The N-terminal region preceding the RBD and the
ordered portion between the RBD and C2 domain are white. b, The
solvent-accessible surface of the enzyme in the same orientation
as in a (prepared with GRASP29). c, Domain organization of the
PI3K classes.
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