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Figure 8.
FIGURE 8. View of the O^6-BzG:T active site superimposed on
the wobble O^6-BzG:ddC-1 pair. A, stereo view of the active site
from the O^6-BzG:T ternary complex is shown superimposed on the
O^6-BzG:ddC-1 structure (r.m.s. deviation = 0.390) with Dpo4 in
schematic diagram form (O^6-BzG:T (ruby), O^6-BzG: ddC-1 (light
blue)). The O^6-BzG:T pair is shown with cyan carbon atoms, and
the O^6-BzG:ddC-1 wobble pair is shown with dark blue carbon
atoms. The O^6-BzG:T calcium ions are red, and the O^6-BzG:ddC-1
calcium ions are dark blue. The incoming dGTP from the O^6-BzG:T
structure is shown in ball and stick form (magenta). B, the p14T
residue (cyan carbon atoms) is shifted up in the active site
relative to p14ddC-1 (dark blue carbon atoms), and the benzyl
group in the O^6-BzG:T structure is shifted slightly toward the
proximal orientation.
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