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Figure 8.
Figure 8. HCV polyprotein processing in the nonstructural
region. Nonstructural proteins NS3, NS4A, NS4B, NS5A and NS5B
are colored purple, red, green, pink and orange, respectively.
(a) Attachment of the 1984-residue polyprotein to the membrane.
(b) NS4A activation and folding of the NS3 N terminus. (c)
Subsequent cleavage reactions. To highlight the fact that the
sequence of cleavage reactions has not been firmly established,
the N terminus of the polyprotein substrate is dotted and the
schematic diagrams are enclosed in a box. (d) The release of
NS4B and NS5A and formation of the replication complex core.
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