|
Figure 7.
FIGURE 7. Human FANCF protein mediates the assembly of the
FA complex via its N and C termini. FANCF may bind to the
preassembled FANCA: FANCG and FANCC:FANCE subcomplexes through
its CTD and N-terminal domain, respectively (Ref. 33 and this
study). Both interactions are necessary to stabilize the FA core
nuclear complex, probably by apposing the FANCC: FANCE and
FANCA:FANCG subcomplexes to facilitate additional interactions
that configure the protein complex for monoubiquitination of
FANCD2.
|
