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Figure 7.
FIGURE 7. Details of the structure of GluR2-S1S2J(Y450W) in
complex with kainate. A, schematic representation of the overall
structure of GluR2-S1S2J(Y450W) with zoom on a F[o] - F[c] omit
map contoured at 3.0  for kainate (blue in D1
and green in D2). B, stereo view of the ligand binding pocket of
GluR2-S1S2J(Y450W) showing the hydrogen-bonding network to
kainate (black). C, comparison of the ligand binding pocket of
wild-type GluR2-S1S2J (6) (PDB code 1FT0 [PDB]
, black) and GluR2-S1S2J(Y450W) (blue in D1 and green in D2),
both in complex with kainate. The side chain of residue 450 is
depicted showing the 6° difference of the aromatic wedge.
Nitrogen atoms are blue, oxygen atoms are red, and sulfur atoms
are yellow. The figure was prepared using Molscript (36) and
Raster3d (37).
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