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Figure 7.
Figure 7. Sparsomycin binding site. Sparsomycin (green) is
sandwiched between the CCA end of P-site bound substrate
analogue, CCA-phe-cap-biotin (large spheres) and the base of
A2637 (2602) (gray sticks). Hydrogen bonds and ionic
interactions are shown as dotted lines. A magnesium ion is
purple and water molecules are small red spheres. The sulfur
(yellow) containing tail of sparsomycin enters the active-site
hydrophobic crevice between A2486 (2451) (gray sticks) and C2487
(2452) (orange sticks, resistance mutation).
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