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Figure 6.
Figure 6. Proposed Structure for the mAb 806-EGFR Complex
(A) Proposed structure for the mAb 806-EGFR complex,
created by structurally aligning model 3 with the hypothetical
extended monomer conformation. The coloring scheme is identical
to that in Figure 5.
(B) Interface interactions: EGFR
residue E293 forms a hydrogen bond with CDR H2 side chain Y50
and makes several hydrophobic contacts, mostly with residues in
the mAb 806 H2 loop.
(C) EGFR residue D297 is well packed
in a pocket of residues from the mAb 806 L2, L3, and H3 CDRs.
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