Figure 6 - full size

Figure 6.
Figure 6. Stereo view showing I-5 bound in the GSK-3b active site. Residues playing a direct or indirect role in inhibitor binding are shown in a ball-and-stick representation. I-5 is shown in light brown; chlorine atoms are in green and water molecules are in red. The C^a trace of GSK-3b is shown in blue and green for the N- and C-terminal domains, respectively. For the sake of clarity, Leu132 and Tyr134 are unlabelled and Val110 has been omitted from the Figure.