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Figure 6.
Figure 6. Stereo view of the Fab 447-52D Antigen Binding
Site(A) As in all figures except Figure 1, the Fab light and
heavy chains are depicted in salmon and blue, with the bound
peptide in yellow. The side chains of the Fab residues in
contact with peptide are shown in a ball-and-stick
representation.(B) A magnified view of the cation-p and salt
bridge interactions between peptide and Fab. The V3 peptide
residue ArgP315 forms a salt bridge with AspH95, and makes
cation-p interactions with the side chains of TyrH100j and
TrpH33. Peptide residue ProP313 is nestled into a cleft formed
by Fab residues TrpL91 and TrpL96, with the Pro ring nearly
coplanar to the TrpL91 indole.
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