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Figure 7.
Figure 7. Potential FERM Domain Interaction SitesThe
positions of five binding sites on proteins that are
structurally similar to the three FERM lobes are indicated: (1)
by analogy with the protein interaction site seen for elongin B
([62]) and the Ras binding domain of Raf kinase ( [47]);
(2) by analogy with the lipid binding site of the acyl CoA
binding protein ( [36]), but this site is blocked by the loop
connecting the F2 helices C and D; (3) by analogy with the
proline-containing peptide binding site on EVH1 domains ( [53];
Federov et al., 1999); (4) by analogy with the canonical peptide
binding site of PTB domains ( [74]); and (5) by analogy with the
inositol phosphate binding sites on PH domains ( [13 and 31]).
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