Figure 6.
Figure 6. Taxonomy of C[2] domains. a, Topologies of the
different subclasses of C[2] domains that have been identified
and that we refer to as topologies IA (SytI C[ 2]A domain and
PKC- C[2]
domain), IB (rabphilin C[ 2]B domain), IIA (PLC- 1
and cPLA[2] C[2] domains) and IIB (PKC- )
(see text). For simplicity, very short -helices
within loops of several C[2] domains have not been included in
the classification. b, Superpositions of the backbone of the
rabphilin C[2]B domain (red) with the backbone of C[2] domains
from the other three subclasses (black). The superpositions with
SytI C[2]A domain (PDB code 1RSY) and the cPLA[2] C[2] domain
(PDB code 1RLW) are shown in the same orientation as Fig. 3a -c
. The superposition with the PKC- C[2]
domain (PDB code 1BDY) is shown with helix 2 in front, as in
Fig. 3d. The positions of secondary structure elements discussed
in the text (strand 8 and helix 2) are indicated.
C[2]
domain), IB (rabphilin C[ 2]B domain), IIA (PLC- 
1
and cPLA[2] C[2] domains) and IIB (PKC- 
-helices
within loops of several C[2] domains have not been included in
the classification. b, Superpositions of the backbone of the
rabphilin C[2]B domain (red) with the backbone of C[2] domains
from the other three subclasses (black). The superpositions with
SytI C[2]A domain (PDB code 1RSY) and the cPLA[2] C[2] domain
(PDB code 1RLW) are shown in the same orientation as Fig. 3a -c
. The superposition with the PKC-