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Figure 5.
Structural basis of H3-K(ac)14 binding to Brd4 BD1. A,
complex structure of the bromodomain 42–166 with the peptide
GGK(ac)A from H3 (green). B, hydrogen bonds between the H3
peptide and the essential asparagine Asn-140 in BD1 define the
interaction network. Several water molecules (colored red) in
the binding cavity of the bromodomain surround the acetyl moiety.
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