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Figure 5.
Fig. 5. Multiple sequence alignment of the PDZ12 tandem of
GRIP from different species. The protein sequences were from
rat, human, zebrafish, and fruit fly. In this diagram, residues
that are identical and similar are shown in red and yellow
boxes, respectively. The secondary structural elements are
indicated above the alignment and are colored blue (for PDZ1)
and green (for PDZ2). The amino acid residues in PDZ1 that are
directly involved in the Fras1 peptide binding are highlighted
with triangles, and the residues labeled with asterisks are
critical for the interdomain interaction between PDZ1 and PDZ2.
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