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Figure 5.
Figure 5: Superposition of NR1-NR2A S1S2 and the GluR2
S1S2-aniracetam complex. a, Overlay of the GluR2 S1S2 dimer
bound to glutamate and aniracetam (Ani, pink) onto the NR1-NR2A
S1S2 dimer (green and blue) viewed from the same angle as in
Fig. 1b. b, Magnification of the NR1 Y535 site and the
aniracetam-binding site viewed from the same angle as in a. Two
water molecules, W1 and W2 (cyan spheres), participate in
stabilizing the NR1-NR2A interaction. c, Side view of the NR1
Y535 site. Note that the position of the aniracetam molecule
(pink) overlaps with that of the aromatic side chain of NR1 Y535.
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