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Figure 5.
Figure 5
Examples of different classes of ligand soaked into
rhFXI[370-607]-S434A,T475A,C482S,K437A-benzamidine crystals. The active site of
rhFXI[370-607]-S434A,T475A,C482S,K437A is presented in a stick representation, with the
catalytic triad (Ser195, His57 and Asp102) and Asp189 labeled. The ligands are in a
ball-and-stick representation and their chemical structures are listed under each picture.
(a) A peptide-mimetic ligand covalently connects to Ser195. (b) A naphthamidine ligand
replaces benzamidine at the active site. (c) A non-basic small compound binds in the S[1]
pocket.
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